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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer’s disease

Fig. 1

a Schematic of in vitro electrophysiological recordings in acute hippocampal slices. b LTP in APP/PS1 hippocampal CA1 rescued by BIX/UNC. c Emetine (EME) blocked the BIX/UNC-mediated LTP rescue. d-f Synaptic tagging and capture was impaired in APP/PS1 hippocampal CA1, but restored by BIX/UNC. g Experiments similar as in d-f but without STET in S1. h Forskolin (FSK)-induced LTP was impaired in APP/PS1 CA1 but rescued by BIX/UNC. Field EPSP values (percentage of baseline) and P values of Wilcoxon test at specified timepoints are presented below each figure in b-h. i SUnSET assay measuring de novo protein synthesis after FSK application with/without BIX/UNC in APP/PS1 slices. j Quantification of puromycin in (i). All data are presented as mean ± SEM. STC: synaptic tagging and capture; STET: strong tetanization protocol; WTET: weak tetanization protocol

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Translational Neurodegeneration

ISSN: 2047-9158

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