Fig. 1

a, b: Representative images of whole-body [¹⁸F]-FDG at the sagittal plane in a WT (a) and an ALS animal (b). Color scale bar indicates radiotracer uptake value normalized for injected dose and weight (SUV). c, d: Horizontal plane of the head in cropped SUV images. From left to right: an individual head-cropped image; an individual brain-masked image; group-based average image; and volume of influence (VOI) placement for data analysis. Color scale bar indicates radiotracer uptake normalized for injected dose and weight (SUV). e, f: Horizontal plane of the head with radioactivity normalized to the average radioactivity in the whole brain (TRR). From left to right: an individual head-cropped image; an individual brain-masked image; group-based average image; and VOI placement for data analysis. Color scale bar indicates radiotracer uptake normalized for averaged radioactivity in the whole brain