Fig. 3

The cortico-hypothalamic projection pattern in mSOD1 mice at P25 at the ipsilateral side was not significantly changed compared to the WT mice. a Left: Representative injection sites in the LHA for WT and mSOD1 mice. White outlines represent LHA boundaries. Middle and right: Representative frontal brain sections of WT and mSOD1 mice depicting a similar pattern of neurons. b Sum of neurons projecting from the selected 28 areas. No difference was detected in the number of neurons projecting to the LHA in WT and mSOD1 from the ipsilateral hemisphere (n = 3). c No difference was detected in the absolute number of neurons projecting to the LHA from the 28 brain areas in WT and mSOD1. d No difference was detected in the 50 k normalized number of neurons projecting to the LHA from the 28 brain areas in WT and mSOD1. Bars show mean ± SD. Scale bars, 1 mm