Fig. 4

Treatment with δ-secretase inhibitor 11 reduced pathological changes of tau in SAMP8 mice. a, b Western blot analysis of AEP and tau N368. *P < 0.05, unpaired Student’s t-test; n = 4 mice per group. c Immunostaining of phospho-tau (Thr231) in cortical and hippocampal neurons. d, e Density of phospho-tau-positive cells in the cortex and hippocampus of SAMP8 mice. *P < 0.05 between groups, unpaired Student’s t-test; n = 5 mice per group