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Fig. 3 | Translational Neurodegeneration

Fig. 3

From: Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer’s disease-related pathologies in a senescence-accelerated mouse model

Fig. 3

Effect of δ-secretase inhibitor 11 treatment on memory function of mice. a, b The swimming speed and escape latency of mice over the 5-day acquisition training. Two-way ANOVA analysis revealed the time effect (F (2.922, 35.06) = 9.659, P < 0.001) and group effect (F (3, 12) = 7.355, P < 0.05) on escape latency. SAMP8 mice learned significantly slower than SAMR1 mice (P < 0.05), and the vehicle-treated SAMP8 mice learned significantly slower than the δ-secretase inhibitor 11-treated SAMP8 mice (P < 0.05). n = 9 mice per group. c, d The percentage of time spent and the distance travelled in the target quadrant in the probe test, which was performed on day 6. *P < 0.05, n = 9 mice per group, one-way ANOVA followed by a Tukey’s post-hoc test

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Translational Neurodegeneration

ISSN: 2047-9158

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