Race modifies default mode connectivity in Alzheimer’s disease

Misiura, Maria B.; Howell, J. Christina; Wu, Junjie; Qiu, Deqiang; Parker, Monica W.; Turner, Jessica A.; Hu, William T.

doi:10.1186/s40035-020-0186-4

Translational Neurodegeneration

Table 5 Factors differentially associated with AD biomarkers according to race (unadjusted p ≤ 0.01), adjusting for age, gender, mean framewise displacement, and APOE ε4 allele

From: Race modifies default mode connectivity in Alzheimer’s disease

Subsystem	Connectivity Pair	Variable Name	B(95% Confidence Interval)	Unadjusted p	Storey’s q
Dorsomedial to midline core	Dorsomedial Prefrontal Cortex to Precuneus	Race	−0.02(−0.30, 0.25)	0.861
		Cognitive impairment	0.04(−0.13, 0.04)	0.292
		*Race Cognitive impairment**	−0.14(0.07, 0.25)	0.005	0.092
	Ventrolateral Temporal Cortex to Precuneus	Race	−0.24(− 0.59, 0.11)	0.170
		Cognitive impairment	−0.08(− 0.02, 0.19)	0.103
		*Race Cognitive impairment**	0.18(0.02, 0.17)	0.001	0.055
		Race	−0.05(−0.32, 0.21)	0.695
		t-Tau	−0.003(− 0.02, − 0.002)	0.712
		*Race t-Tau**	0.02(−0.03, − 0.0002)	0.001	0.055
	Dorsomedial Prefrontal cortex to Posterior Cingulate Cortex	Race	0.29(0.08, 0.50)	0.007
		Cognitive Impairment	0.05(−0.15, 0.03)	0.407
		*Race Cognitive impairment**	0.18(0.02, 0.17)	0.007	0.096
	Temporal Pole to Precuneus	Race	0.05(−0.18, −0.29)	0.667
		Aβ42	0.0003(0.00, 0.01)	0.345
		*Race Aβ42**	−0.001(−0.002, − 0.00001)	0.004	0.073
		Race	−0.80(− 0.29, 0.13)	0.442
		t-Tau	−0.002(− 0.01, − 0.001)	0.736
		*Race t-Tau**	0.003(0.001, 0.006)	0.005	0.069
	Dorsolateral Temporal Cortex to Precuneus	Race	−0.21(−0.12, 0.36)	0.112
		Aβ42	0.0002(−0.0001, 0.01)	0.345
		*Race Aβ42**	−0.002(− 0.003, − 0.00001)	0.002	0.055
		Race	−0.21(− 0.43, 0.02)	0.070
		t-Tau	−0.001(− 0.002, − 0.02)	0.066
		*Race t-Tau**	0.004(0.001, 0.006)	0.003	0.083
		Race	−0.074(− 0.20,0.54)	0.004
		Cognitive impairment	0.27(−0.04,0.09)	0.001
		*Race Cognitive impairment**	0.20(0.05, 0.25)	0.002	0.055
MTL to midline core	Posterior Cingulate to Hippocampus	Race	−0.001(−0.22, 0.22)	0.900
		t-Tau	−0.001(− 0.03, 0.002)	0.199
		*Race t-Tau**	0.003(0.001, 0.052)	0.004	0.073

Unadjusted p-values which remain significant after Benjamini-Hochberg step-up correction for multiple comparisons are bolded. Storey’s q-values are also shown with FDR < 10%. MTL Medial Temporal Lobe, IPL inferior parietal lobule

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