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Table 5 Factors differentially associated with AD biomarkers according to race (unadjusted p ≤ 0.01), adjusting for age, gender, mean framewise displacement, and APOE ε4 allele

From: Race modifies default mode connectivity in Alzheimer’s disease

SubsystemConnectivity PairVariable NameB(95% Confidence Interval)Unadjusted pStorey’s q
Dorsomedial to midline coreDorsomedial Prefrontal Cortex to PrecuneusRace−0.02(−0.30, 0.25)0.861 
Cognitive impairment0.04(−0.13, 0.04)0.292 
Race * Cognitive impairment−0.14(0.07, 0.25)0.0050.092
Ventrolateral Temporal Cortex to PrecuneusRace−0.24(− 0.59, 0.11)0.170 
Cognitive impairment−0.08(− 0.02, 0.19)0.103 
Race * Cognitive impairment0.18(0.02, 0.17)0.0010.055
Race−0.05(−0.32, 0.21)0.695 
t-Tau−0.003(− 0.02, − 0.002)0.712 
Race * t-Tau0.02(−0.03, − 0.0002)0.0010.055
Dorsomedial Prefrontal cortex to Posterior Cingulate CortexRace0.29(0.08, 0.50)0.007 
Cognitive Impairment0.05(−0.15, 0.03)0.407 
Race * Cognitive impairment0.18(0.02, 0.17)0.0070.096
Temporal Pole to PrecuneusRace0.05(−0.18, −0.29)0.667 
Aβ420.0003(0.00, 0.01)0.345 
Race * Aβ42−0.001(−0.002, − 0.00001)0.0040.073
Race−0.80(− 0.29, 0.13)0.442 
t-Tau−0.002(− 0.01, − 0.001)0.736 
Race * t-Tau0.003(0.001, 0.006)0.0050.069
Dorsolateral Temporal Cortex to PrecuneusRace−0.21(−0.12, 0.36)0.112 
Aβ420.0002(−0.0001, 0.01)0.345 
Race * Aβ42−0.002(− 0.003, − 0.00001)0.0020.055
Race−0.21(− 0.43, 0.02)0.070 
t-Tau−0.001(− 0.002, − 0.02)0.066 
Race * t-Tau0.004(0.001, 0.006)0.0030.083
Race−0.074(− 0.20,0.54)0.004 
Cognitive impairment0.27(−0.04,0.09)0.001 
Race * Cognitive impairment0.20(0.05, 0.25)0.0020.055
MTL to midline corePosterior Cingulate to HippocampusRace−0.001(−0.22, 0.22)0.900 
t-Tau−0.001(− 0.03, 0.002)0.199 
Race * t-Tau0.003(0.001, 0.052)0.0040.073
  1. Unadjusted p-values which remain significant after Benjamini-Hochberg step-up correction for multiple comparisons are bolded. Storey’s q-values are also shown with FDR < 10%. MTL Medial Temporal Lobe, IPL inferior parietal lobule