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Table 1 Demographic information for the final cohort who passed imaging quality control process

From: Race modifies default mode connectivity in Alzheimer’s disease

 Overall (N = 137)Normal cognitionMCIAD
 Caucasian (n = 72)African American (n = 65)Caucasian (n = 31)African American (n = 27)Caucasian (n = 25)African American (n = 28)Caucasian (n = 16)African American (n = 10)
Age, years (SD)70.90 (7.84)69.20 (7.49)71.65 (8.39)*67.48 (6.17)*71.52 (5.82)70.07 (7.74)68.50 (9.41)71.4 (9.65)
Women (Men)35 (37)43 (29)19 (12)17 (10)15 (10)12 (16)9 (7)6 (4)
Years of Education (SD)16.32 (2.85)16.15 (2.85)16.81 (2.69)15.78 (2.66)17.08 (2.58)16.29 (2.81)14.19 (1.94)16.80 (3.55)
MMSE (SD)26.32 (4.90)26.91 (3.57)28.84 (0.86)28.00 (1.86)27.64 (1.68)26.67 (2.34)21.37 (3.38)20.22 (6.18)
Cognitive Z Scores (SD)−0.78 (1.12)−0.72 (0.99)0.07 (0.51)−0.11 (0.51)− 0.88 (0.86)− 0.67 (0.59)−2.24 (0.66)−2.36 (1.02)
White Matter Hyperintensity volume (mm3)3984.40 (4110.10)3886.03 (4964.93)3306.81 (3337.32)2440.93 (2576.15)4018.66 (4080.03)4313.70 (5330.60)5243.68 (5333.14)6730.21 (7607.48)
Having ABCA7 risk allele, (%)23.67*43.10*29.0044.4024.0050.0012.5030.00
Have Diabetes, (%)5.67**33.80**6.50**33.33**0*28.60*12.50*50.00*
Have Hypertension (%)45.83**72.31**45.1662.9656.0078.5731.25*80.00*
CSF Aβ42, pg/ml (SD)148.35 (95.02)168.48 (128.86)199.93 (132.30)165.27 (89.8)199.11 (141.02)134.69 (90.99)77.65 (47.39)133.55 (140.71)
CSF t-Tau, pg/ml (SD)72.84 (49.63)**40.92 (20.79)**51.68 (30.96)**36.04 (11.63)**63.99 (33.71)*35.44 (13.67)*108.48 (77.43)75.8 (33.52)
CSF p-Tau181, pg/ml (SD)17.58 (8.97)**25.81 (12.47)**23.47 (9.71)**14.05 (5.07)**25.01 (13.42)*17.74 (7.21)*33.53 (14.64)24.54 (10.27)
CSF t-Tau/Aβ420.73 (0.91)*0.24 (0.22)*0.46 (0.74)*0.15 (0.12)*0.44 (0.42)*0.22 (0.14)*1.36 (1.16)0.55
(0.41)
  1. Note: T-tests were performed to compare races in the whole cohort and within each diagnostic category. *p < .05, **p < .001. MMSE and CogZ scores were significantly different between diagnostic categories such, NC having highest MMSE scores and AD having lowest (MMSE: NC vs MCI, p = .007, MCI vs AD, p < .0001, CogZ: NC vs MCI, p < .0001, MCI vs AD, p < .0001)