Fig. 4
From: Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
Model of the PINK1/Parkin-mediated polyubiquitination of MOM upon mitochondrial depolarization. Under basal conditions, ubiquitination in mitochondria is balanced by resident ubiquitin E3 ligases (e.g., MITOL) and deubiquitination enzymes (e.g., USP30) (left panel). However, upon mitochondrial depolarization, stabilized PINK1 promotes the Parkin-dependent generation of ubiquitin chains on MOM (right panel)