Fig. 1

Higher NPI-Q and shorter EYO of AD were associated with higher [¹⁸F]FDG uptake decline in DIAD mutation carriers. Statistical parametric map overlaid on a structural MRI scan shows regions in the PCC (a), vmPFC (b), bilateral parietal lobes (c) and right AI (d) where higher [¹⁸F]FDG uptake decline was found in cognitively normal DIAD mutation carriers with higher NPI-Q scores and shorter EYO of AD. The analysis was corrected for gender, education, APOE ε4 status and family mutation type (APP, PSEN1 and PSEN2) and multiple comparisons were corrected using random field theory at p <  0.001. AD: Alzheimer disease; AI: anterior insula; DIAD: dominantly inherited Alzheimer’s disease; EYO: estimated years to onset; [¹⁸F]FDG: [¹⁸F]fluorodeoxyglucose; NPI-Q: Neuropsychiatric Inventory; PCC: posterior cingulate cortex; vmPFC: ventromedial prefrontal cortex