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Fig. 6 | Translational Neurodegeneration

Fig. 6

From: Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance

Fig. 6

Effects of single or combined treatment with Anle 138b and PD03 on microglial activation in SNc. a CD68 immunohistochemistry in SNc (left) and a violin plot of the density of activated microglia in CD68 immunohistochemistry in SNc (right). *P < 0.05, **P < 0.01, one-way ANOVA with post-hoc Bonferroni test. b Iba-1 immunohistochemistry in SNc. Scale bars, 100 μm. c Total number of Iba-1-immunoreactive microglia in the SNc of PLP-α-syn mice receiving different treatment. d Percentage of homeostatic (type A) Iba-1-immunoreactive microglia in the SNc of PLP-α-syn mice receiving different treatment. e Percentage of B-type activated Iba-1-immunoreactive microglia in the SNc of PLP-α-syn mice receiving different treatments. f Percentage of activated (C-D type) Iba-1-immunoreactive microglia in the SNc of PLP-α-syn mice receiving different treatments. *P < 0.05, **P < 0.01, one-way ANOVA with post-hoc Bonferroni test

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Translational Neurodegeneration

ISSN: 2047-9158

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