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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer’s disease

Fig. 5

Summary of lipid module/protein module associations with AD risk loci. AD genetic variants IL34, MEF2C, ABCA7, PLCG2 and CR1 were correlated with the green, darkturquoise, and midnightblue lipid modules, which had established functions of immune response and inflammation, cholesterol metabolism, lipid transport, and immune and complements systems. Two protein modules, cyan and red, were linked with immune response through over-representation analysis, while AD genetic variants MS4A6A, HLA-DLB1 and IL34, which were correlated with protein modules, also had immune response functions

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Translational Neurodegeneration

ISSN: 2047-9158

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