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Table 2 Burden analysis of GCH1 non-coding variants in the WGS cohort

From: GCH1 variants contribute to the risk and earlier age-at-onset of Parkinson’s disease: a two-cohort case-control study

Groups Items Rare variant set analysis All variant set analysis
Variants included P value (SKAT-O) Variants included P value (SKAT-C)
UTRs/introns (NM_000161) UTRs/introns 1258 0.80 1403 0.03
Promoter/Enhancer GH14J054782 128 0.44 146 0.41
GH14J054818 24 1 28 0.50
GH14J054843 58 0.46 63 0.09
GH14J054857 44 0.03 47 0.05
GH14J054880 35 0.28 50 0.02
GH14J054889 134 0.74 149 0.82
GH14J054900 79 0.41 90 0.37
GH14J054908 9 0.73 11 0.35
All 511 0.72 584 0.15
eQTLs brain specific eQTLs 7 0.18 119 0.02