The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline

Table 2 Global properties of functional network in HC and SCD

Global properties	HC	SCD	P value
Network strength	13.13 ± 3.21	14.90 ± 3.02	0.002*
Clustering coefficient	0.33 ± 0.04	0.35 ± 0.03	0.001*
Shortest path length	3.37 ± 0.34	3.20 ± 0.28	0.001*
Small-worldness	1.12 ± 0.15	1.05 ± 0.09	0.002*
Global efficiency	0.30 ± 0.03	0.31 ± 0.03	0.001*
Local efficiency	0.32 ± 0.02	0.33 ± 0.02	0.002*
Hierarchy	0.02 ± 0.13	−0.001 ± 0.13	0.387
Assortativity	−0.04 ± 0.11	−0.09 ± 0.16	0.067

Significantly increased network strength, clustering coefficient, global efficiency and local efficiency in the SCD group compared with the HC group (P < 0.05, uncorrected). The shortest path length and small-worldness in the SCD group was significantly lower than that in the HC group (P < 0.05, uncorrected). No statistical significance was observed in the hierarchy coefficient and assortativity coefficient between HC and SCD group
Abbreviations: HC Health control, SCD Subjective cognitive decline
*indicates a statistical difference between groups, p < 0.05

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