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Table 3 Patients with dementia due to AD stratified according to the A/T/N

From: Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

A/T/(N) system

Biomarker group

AD biomarker concordance

n

A+/T+/N+ (n = 21)

A+

Concordance between amyloid PET and CSF-Aβ42

10

Either amyloid PET or CSF-Aβ42 positivity

3

Only CSF-Aβ42 available

8

N+

Concordance between FDG PET, CSF-tTau and atrophy (cMRI)

18

Concordance between atrophy (cMRI) and either FDG-PET or CSF-tTau positivity

3

A+/T−/N+ (n = 11)

A+

Concordance between amyloid PET and CSF-Aβ42

5

Either amyloid PET or CSF-Aβ42 positivity

2

Only CSF-Aβ42 available

4

N+

Concordance between FDG PET, CSF-tTau and atrophy (cMRI)

6

Concordance between atrophy (cMRI) and either FDG-PET or CSF-tTau positivity

3

  1. A+ Amyloid pathology, T Tau pathology, N Neuronal injury, PET Position emission tomography, CSF Cerebral spinal fluid, cMRI cranial magnetic resonance imaging, FDG-PET [18F]fluorodeoxyglucose-position emission tomography, amyloid β