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Table 2 Levels of KLK6, KLK8 and KLK10 in CSF of NC and patients with AD stratified to the A/T/(N) system

From: Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

 

AD A+/T+/N+ (n = 21)

AD A+/T−/N+ (n = 11)

NC A−/T−/N- (n = 23)

CSF-KLK6 ng/ml

372 ± 106.2 (243–663)

224 ± 56.7 (132–312)

220 ± 62.4 (101–344)

CSF-KLK8 ng/ml

0.16 ± 0.024 (0.12–0.21)

0.16 ± 0.031 (0.12–0.22)

0.16 ± 0.058 (0.10–0.37)

CSF-KLK10 ng/ml

0.69 ± 0.220 (0.32–1.11)

0.61 ± 0.26 (0.22–1.03)

0.48 ± 0.249 (0.08–0.95)

  1. KLK Kallikrein-related peptidase, AD Alzheimer’s dementia, NC normal controls, A amyloid pathology, T Tau pathology, N Neuronal injury
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Translational Neurodegeneration

ISSN: 2047-9158

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