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Fig. 5 | Translational Neurodegeneration

Fig. 5

From: Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET

Fig. 5

Regional regression analyses between CSF-KLK6 and CSF-KLK10, respectively, and the regional FDG-PET uptake signal. Voxel based regional regression analysis between CSF-KLK6 (a) and KLK10 (b) and the FGD-PET signal. a Significant (p < 0.05 FDR corrected) positive associations of KLK6 with the C/p [18F]FDG-PET signal and b KLK10 with the C/th [18F]FDG-PET signal. Correlations are depicted in red to yellow (increasing T values) and are projected on axial T1 MRI scans (average of 152 scans, implemented in SPM12), numbers indicate z-coordinates of slices in Talairach space in mm. For exact cluster distribution compare Additional file 1: Table 4B-C. CSF: cerebrospinal fluid; KLK: kallikrein-related peptidase, ApoE: apolipoprotein E; C/p: Cerebrum to pons; C/th: Cerebrum to thalamus; [18F]FDG-PET: [18F]fluorodeoxyglucose-position emission tomography

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