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Table 1 Clinical data and OM/RT-QuIC results of all patients included in the study

From: Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy

  PD MSA CBD PSP
Clinical criteria (ref.) [18, 61] [33] [62] [39]
Number of patients 18 11 6 12
Age at time of evaluation (years) 64.2 ± 7.8 62.3 ± 9.2 63.3 ± 10.6 68.3 ± 7.0
Age at disease onset (years) 52.4 ± 6.1 56.5 ± 9.5 60.2 ± 10.9 64.3 ± 8.2
Disease duration (years) 10.1 ± 5.1 5.8 ± 3.4 3.2 ± 1.6 4.0 ± 3.6
Gender (F/M) 8/10 5/6 4/2 5/7
Frequency of symptoms (%)
• Rigid akinetic parkinsonism 100 90.1 83.3 91.7
• Tremor 88.9 81.8 50 8.3
• Ataxia 0 90.1 50 91.7
• Apraxia 0 0 100 33.3
• Delusions 16.7 9.1 0 8.3
• Dementia 11.1 0 16.7 58.3
• Psychiatric disorders 33.3 45.5 33.3 50
• REM behavioural disorder 55.6 63.6 0 0
• Autonomic impairment 83.3 100 33.3 16.7
RT-QuIC seeding activity for α-synuclein (% in total patients) 10 (56%) 9 (82%) 1 (16%) 2 (16%)
  1. Values of continuous variables are presented as mean ± standard deviation (SD)