Table 1 Clinical data and OM/RT-QuIC results of all patients included in the study
PD | MSA | CBD | PSP | |
|---|---|---|---|---|
Clinical criteria (ref.) | [33] | [62] | [39] | |
Number of patients | 18 | 11 | 6 | 12 |
Age at time of evaluation (years) | 64.2 ± 7.8 | 62.3 ± 9.2 | 63.3 ± 10.6 | 68.3 ± 7.0 |
Age at disease onset (years) | 52.4 ± 6.1 | 56.5 ± 9.5 | 60.2 ± 10.9 | 64.3 ± 8.2 |
Disease duration (years) | 10.1 ± 5.1 | 5.8 ± 3.4 | 3.2 ± 1.6 | 4.0 ± 3.6 |
Gender (F/M) | 8/10 | 5/6 | 4/2 | 5/7 |
Frequency of symptoms (%) | ||||
• Rigid akinetic parkinsonism | 100 | 90.1 | 83.3 | 91.7 |
• Tremor | 88.9 | 81.8 | 50 | 8.3 |
• Ataxia | 0 | 90.1 | 50 | 91.7 |
• Apraxia | 0 | 0 | 100 | 33.3 |
• Delusions | 16.7 | 9.1 | 0 | 8.3 |
• Dementia | 11.1 | 0 | 16.7 | 58.3 |
• Psychiatric disorders | 33.3 | 45.5 | 33.3 | 50 |
• REM behavioural disorder | 55.6 | 63.6 | 0 | 0 |
• Autonomic impairment | 83.3 | 100 | 33.3 | 16.7 |
RT-QuIC seeding activity for α-synuclein (% in total patients) | 10 (56%) | 9 (82%) | 1 (16%) | 2 (16%) |