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Table 1 The presence of ocular abnormalities according to chronological order from disease durations including early stage (< 4 years), middle stage (4–8 years), and late stage (> 8 years) among autopsy-proven cases of PSP and its variants

From: How to spot ocular abnormalities in progressive supranuclear palsy? A practical review

PSP subtypes SWJ SS VSP RTH DBR BSP ALO
PSP-RS +++
(early to middle stage manifestation)
++
(early to middle stage manifestation)
+++
(early to middle stage manifestation)
++
(early stage manifestation)
+
(middle to late stage manifestation)
+
(middle to late stage manifestation)
+
(middle to late stage manifestation)
PSP-OM N/A N/A ++ N/A N/A N/A N/A
PSP-PI Absent +
(late stage manifestation)
+
(late stage manifestation)
Absent Absent Absent +
(late stage manifestation)
PSP-P N/A +
(middle to late stage manifestation)
+
(middle to late stage manifestation)
N/A N/A N/A N/A
PSP-Frontal Absent Absent Absent Absent Absent Absent Absent
PSP-PGF Absent +
(middle to late stage manifestation)
+
(middle to late stage manifestation)
Absent Absent +
(late stage manifestation)
Absent
PSP-CBS N/A +
(early to middle stage manifestation)
+
(early to middle stage manifestation)
N/A N/A N/A N/A
PSP-PLS Absent Absent Absent
(still absent over 10-year duration)
Absent Absent Absent Absent
PSP-C N/A N/A +
(early to middle stage manifestation)
N/A N/A N/A N/A
PSP-SL Absent Absent +
(middle stage manifestation)
Absent Absent Absent Absent
  1. The information described in this table was pooled from this systematic review
  2. SWJ Square wave jerks, SS Slow saccades, VSP Vertical supranuclear palsy, RTH Round the house sign, DBR Decreased blink rate, BSP Blepharospasm, ALO Apraxia of eyelid opening, PSP-OM PSP-ocular motor dysfunction, PSP-PI PSP-postural instability, PSP-P PSP-parkinsonism, PSP-frontal PSP-frontal, PSP-PGF PSP-progressive gait freezing, PSP-CBS PSP-corticobasal syndrome, PSP-PLS PSP-primary lateral sclerosis, PSP-C PSP-cerebellum, and PSP-SL PSP-speech/language disorders