Fig. 7

Levels of LAMP-1/-2A, α-syn-GFP and (mouse endogenous) α-syn in BAC-α-syn-GFP transgenic mice. Representative Western blots (a, b) and intensity quantification (c, d) of related proteins normalized to actin are shown (8 animals/group, male). The results show a significant difference between the regions of the CS and SNpc for LAMP-1 and LAMP-2A in DHM (a) and Sal B (b) treated groups and the saline-control group. The levels of LAMP-1 and LAMP-2A were significantly increased, while the levels of α-syn-GFP (the product of the transgene) were significantly decreased by DHM and Sal B treatments. However, the levels of mouse endogenous α-syn were not significantly different among the groups. Significant differences are indicated as DHM (c) and Sal B (d) treatments in the CS and SNpc compared with the saline treated group. All data shown are representative of at least three independent experiments (mean ± SD, *p<0.05, **p<0.01)