Fig. 2
From: Current progress of mitochondrial transplantation that promotes neuronal regeneration
Mechanisms underlying mitochondria internalization. Three uptake routes for mitochondrial therapy: a Mitochondria-containing vesicles are released from healthy neurons (or donor cells) and then internalized into injured neurons. b Healthy mitochondria are transported via the actin-based tunneling nanotubes between donor cells and injured neurons. c Extracellular healthy mitochondria through focal administration are internalized into injured neuron