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Fig. 7 | Translational Neurodegeneration

Fig. 7

From: Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

Fig. 7

LDclns induced dopaminergic neuron loss in A53T mice. a Immunohistochemical staining of TH-positive neurons in SNc of mice. b Stereological counts revealed that numbers of TH-positive neurons significantly decreased in A53T-LDclns mice (genotype, F(1,12) = 5.959, p = 0.0311; ligament, F(1,12) = 13.35, p = 0.0033; interaction, F(1,12) = 3.724, p = 0.0776). c-d Representative immunoblotting bands and densitometry analysis of TH expression that significantly decreased in A53T mice after LDclns (genotype, F(1,12) = 14.70, p = 0.0024; ligament, F(1,12) = 17.26, p = 0.0013; interaction, F(1,12) = 8.222, p = 0.0142). Data represent mean ± SEM from 4 mice per group; data in d are from two independent experiments

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Translational Neurodegeneration

ISSN: 2047-9158

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