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Table 4 Apolipoprotein E-adjusted estimates of the association of 5-hydroxytriptamine transporter gene-linked polymorphic region (5-HTTLPR) S-plus carriers with clinical characteristics in patients with Alzheimer’s disease (AD) according to to the presence of delusion symptom

From: Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer’s disease

  All AD-D AD-noD
  p OR (95%CI) p OR (95%CI) p OR (95%CI)
MNA 0.464 1.892 (3.449 × 10−1 - 1.038 × 101) 0.884 1.157 (0.163–8.205) 0.830 0.607 (5.772 × 10−3 - 6.375 × 101)
ADL 0.930 0.978 (0.582–1.640) 0.702 0.886 (0.478–1.644) 0.200 0.449 (0.132–1.528)
IADL 0.349 1.383 (0.703–2.720) 0.420 1.356 (0.644–2.855) 0.367 0.418 (0.064–2.745)
CIRS-CI 0.979 1.007 (0.582–1.750) 0.605 0.848 (0.454–1.583) 0.154 3.162 (0.667–15.002)
ESS 0.220 1.810 (0.709–4.600) 0.400 1.600 (0.543–4.715) 0.310 0.265 (0.021–3.414)
SPMSQ 0.993 1.000 (0.611–1.650) 0.943 1.022 (0.570–1.830) 0.140 2.310 (0.770–6.931)
Age at onset 0.706 1.380 (0.259–7.350) 0.539 0.528 (0.069–4.031) 0.320 6.104 (1.748 × 10−1 - 2.132 × 102)
Disease duration 0.011 0.740 (0.587–0.933) 0.005 0.680 (0.522–0.886) 0.700 1.116 (0.640–1.947)
MMSE 0.996 1.000 (0.223–4.510) 0.888 0.880 (0.148–5.215) 0.210 0.121 (4.464 × 10−3 - 3.290)
NPI 0.950 0.854 (4.530 × 10−3 - 1.610 × 102) 0.235 4.796 × 101 (8.237 × 10−2 - 2.792 × 104) 0.420 5.490 × 101 (3.419 × 10− 3 - 8.817 × 105)
NPI-Distress 0.870 1.180 (0.153–9.150) 0.074 9.564 (8.161 × 10 −1 - 1.121 × 10 2 ) 0.234 7.960 (2.282 × 10−1 - 2.362 × 102)
  1. AD-D AD patients with delusions, AD-noD AD patients without delusions, OR odds ratio, CI confidence interval, MNA Mini Nutritional Assessment, ADL Activities of Daily Living, IADL Instrumental Activities of Daily Living, CIRS-CI Cumulative Illness Rating Scale Comorbidity Index, ESS Exton-Smith Scale, SPMSQ Short Portable Mental Status Questionnaire, MMSE Mini-Mental State Examination, NPI Neuropsychiatric Inventory