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Table 1 Demographic and clinical characteristics of Alzheimer’s disease (AD) patients according to the presence of delusion symptom

From: Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer’s disease

   AD-D AD-noD p All
   (n = 171) (n = 86) (N = 257)
Sexa (M/F) 55/116 27/59 0.999 82/175
(Ratio) 0.47 0.46   0.47
Age (Years) 79.84 ± 6.80 80.97 ± 6.22 0.254 80.21 ± 6.62
Body mass index (Kg/m2) 26.81 ± 5.89 25.15 ± 6.03 0.106 26.30 ± 5.95
Educational level (Years) 4.25 ± 3.83 4.26 ± 3.49 0.798 4.26 ± 3.72
Social support networkb Living alone 34 (19.88%) 2 (2.33%) 0.000 36 (14.01%)
Living with family 112 (65.50%) 82 (95.35%)   194 (75.49%)
Institutionalized 25 (14.62%) 2 (2.33%)   27 (10.51%)
Concomitant treatments (No. of drugs) 6.60 ± 3.07 5.08 ± 3.12 0.026 6.15 ± 3.14
Clinical characteristics
 MNA   18.81 ± 5.77 20.98 ± 5.64 0.011 19.48 ± 5.81
 ADL   3.27 ± 1.98 3.89 ± 1.86 0.025 3.47 ± 1.96
 IADL   2.05 ± 2.39 2.87 ± 2.81 0.037 2.31 ± 2.55
 CIRS-CI   2.74 ± 1.62 2.73 ± 1.74 0.870 2.74 ± 1.66
 ESS   14.50 ± 3.29 15.80 ± 3.29 0.008 14.89 ± 3.33
 SPMSQ   5.29 ± 1.93 4.75 ± 1.87 0.014 5.11 ± 1.93
 Age at onsetc (Years) 78.03 ± 6.68 78.84 ± 6.16 0.143 78.02 ± 6.53
 Disease duration (Years) 2.23 ± 0.88 2.09 ± 0.94 0.226 2.18 ± 0 90
 MMSE   16.81 ± 5.92 18.33 ± 5.64 0.017 17.32 ± 5.86
 NPI   35.57 ± 20.94 22.72 ± 17.04 0.000 31.14 ± 20.57
 NPI-Distress   15.71 ± 8.08 9.32 ± 5.96 0.000 13.58 ± 8.02
 Delusion symptom duration (Years) 2.99 ± 0.79 1.39 ± 1.18
 Delusion symptom severity   6.38 ± 3.25 4.27 ± 4.01
  1. Values of continuous variables are presented as mean ± standard deviation (SD)
  2. aFisher’s Exact Test for Count Data; bPearson’s Chi-squared test; cWelch Two Sample t-test. All the other variables were compared by the Wilcoxon rank sum test with continuity correction
  3. AD-D AD patients with delusions, AD-noD AD patients without delusions, MNA Mini Nutritional Assessment, ADL Activities of Daily Living, IADL Instrumental Activities of Daily Living, CIRS-CI Cumulative Illness Rating Scale Comorbidity Index, ESS Exton-Smith Scale, SPMSQ Short Portable Mental Status Questionnaire, MMSE Mini-Mental State Examination, NPI Neuropsychiatric Inventory