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Table 1 Demographic and clinical characteristics of Alzheimer’s disease (AD) patients according to the presence of delusion symptom

From: Hydroxytryptamine transporter gene-linked polymorphic region (5HTTLPR) is associated with delusions in Alzheimer’s disease

  

AD-D

AD-noD

p

All

  

(n = 171)

(n = 86)

(N = 257)

Sexa

(M/F)

55/116

27/59

0.999

82/175

(Ratio)

0.47

0.46

 

0.47

Age

(Years)

79.84 ± 6.80

80.97 ± 6.22

0.254

80.21 ± 6.62

Body mass index

(Kg/m2)

26.81 ± 5.89

25.15 ± 6.03

0.106

26.30 ± 5.95

Educational level

(Years)

4.25 ± 3.83

4.26 ± 3.49

0.798

4.26 ± 3.72

Social support networkb

Living alone

34 (19.88%)

2 (2.33%)

0.000

36 (14.01%)

Living with family

112 (65.50%)

82 (95.35%)

 

194 (75.49%)

Institutionalized

25 (14.62%)

2 (2.33%)

 

27 (10.51%)

Concomitant treatments

(No. of drugs)

6.60 ± 3.07

5.08 ± 3.12

0.026

6.15 ± 3.14

Clinical characteristics

 MNA

 

18.81 ± 5.77

20.98 ± 5.64

0.011

19.48 ± 5.81

 ADL

 

3.27 ± 1.98

3.89 ± 1.86

0.025

3.47 ± 1.96

 IADL

 

2.05 ± 2.39

2.87 ± 2.81

0.037

2.31 ± 2.55

 CIRS-CI

 

2.74 ± 1.62

2.73 ± 1.74

0.870

2.74 ± 1.66

 ESS

 

14.50 ± 3.29

15.80 ± 3.29

0.008

14.89 ± 3.33

 SPMSQ

 

5.29 ± 1.93

4.75 ± 1.87

0.014

5.11 ± 1.93

 Age at onsetc

(Years)

78.03 ± 6.68

78.84 ± 6.16

0.143

78.02 ± 6.53

 Disease duration

(Years)

2.23 ± 0.88

2.09 ± 0.94

0.226

2.18 ± 0 90

 MMSE

 

16.81 ± 5.92

18.33 ± 5.64

0.017

17.32 ± 5.86

 NPI

 

35.57 ± 20.94

22.72 ± 17.04

0.000

31.14 ± 20.57

 NPI-Distress

 

15.71 ± 8.08

9.32 ± 5.96

0.000

13.58 ± 8.02

 Delusion symptom duration

(Years)

2.99 ± 0.79

1.39 ± 1.18

 Delusion symptom severity

 

6.38 ± 3.25

4.27 ± 4.01

  1. Values of continuous variables are presented as mean ± standard deviation (SD)
  2. aFisher’s Exact Test for Count Data; bPearson’s Chi-squared test; cWelch Two Sample t-test. All the other variables were compared by the Wilcoxon rank sum test with continuity correction
  3. AD-D AD patients with delusions, AD-noD AD patients without delusions, MNA Mini Nutritional Assessment, ADL Activities of Daily Living, IADL Instrumental Activities of Daily Living, CIRS-CI Cumulative Illness Rating Scale Comorbidity Index, ESS Exton-Smith Scale, SPMSQ Short Portable Mental Status Questionnaire, MMSE Mini-Mental State Examination, NPI Neuropsychiatric Inventory