Table 3 Demographic and clinical features of familial and sporadic ALS patients with SOD1 mutations
From: Better survival in female SOD1-mutant patients with ALS: a study of SOD1-related natural history
|  | Case count, n (%) | Bulbar site at onset, n (%) | AAO, years, mean (SD) | Delay, months, median (IQR) | Disease progression, ΔFS, median (IQR) | Survival time, months, mean (95% Cl)& |
|---|---|---|---|---|---|---|
Total | 66 | 5(8.1%) | 43.92(9.24) | 14.50(6.00–36.50) | 0.33 (0.15–0.90) | 97.08 (75.61–118.54) |
Missing | – | 4 | 2 | 2 | 9 | 5 |
fALS | 47(71.2%) | 3(7.0%) | 43.49(7.50) | 20.00(6.50–39.00) | 0.27(0.15–0.87) | 87.46(61.74–113.18) |
sALS | 19(28.8%) | 2(10.5%) | 44.95(12.63) | 8.00(6.00–25.00) | 0.58(0.14–0.98) | 121.49(86.24–156.74) |
p value | – | 0.638 | 0.64 | 0.26 | 0.59 | 0.38 |
Male | 35(53.8%) | 4(11.8%) | 44.62(10.38) | 9.50(4.75–24.25) | 0.55(0.24–0.94) | 57.40(38.89–75.91) |
Female | 30(46.2%) | 1(3.6%) | 43.13(7.84) | 24.00(9.50–47.50) | 0.19(0.06–0.90) | 125.64(99.83–151.45) |
p value | -# | 0.366 | 0.525 | 0.009* | 0.041* | 0.006* |