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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

Fig. 2

InRapa improves cognitive performances in TS65Dn mice. Panel a and b represent data of the novel object recognition test. Values shown in the bar graph are in (a) Preference index and in (b) Discrimination index (data presented are mean ± SEM n = 10/ group). Statistical significance was determined using one–way ANOVA and post hoc Bonferroni t-test (*p < 0.05, **p < 0.01). Panels from c to h represent Radial Arm Maze (RAM) results for our treatment groups of treatment. The red and black triangles are data from Ts65Dn mice treated with InRapa and Veh solution. The blue filled circles are data from Eu mice treated with InRapa and the empty circle are data from Eu mice treated with Veh solution. Panel c represents the latency of the mice on each trial (one trial per day). Panel d represents bar diagram showing latency during the test day (day 10). Panel e represents the working memory errors committed by mice on each trial (one trial per day). Panel f represents bar diagram showing working memory error during the test day (day 10). Panel g represents the reference memory errors committed by mice on each trial (one trial per day). Panel h represents bar diagram showing reference memory error during the test day (day 10) values shown in the bar graph are the mean of 10 samples per each group

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