From: Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice
MRI markers | White Matter Microstructure | Histology/Molecular Markers |
---|---|---|
FA ↓ | Axonal Organization | YFP labeled axons |
RD ↑ | Myelin Content | MBP ↓* |
AD ↓ | Axonal Degeneration | YFP labeled axons |
EW ↓ | Axonal Connectivity | YFP labeled axons |
ADC ↑ | Transmembrane Water Diffusion | AQP4 ↑↑ |