Table 2 Physiological roles of different isoform of NOS

eNOS

 • Preservation and maintenance of brain’s microcirculation [21].

 • Inhibition of platelet aggregation [131].

 • Reduction of smooth muscle proliferation [21, 39]

nNOS

Important roles in memory formation, CNS blood flow, neuronal plasticity, transmission of pain signals [21].

iNOS

Response to proinflammatory cytokines or endotoxins [21].