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Table 2 Correlations between tau antibody binding ratios, subject age, cognitive scores, and NFT counts using all study subjects

From: Specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and Alzheimer’s disease subjects: an exploratory study

  pTau IgG non-pTau IgM pTau IgM Age Global Cognition NFT counts
Non-pTau IgG −0.14 −0.01 0.12 0.55 −0.50 0.14
0.47 0.95 0.51 0.002 0.005 0.46
pTau IgG   −0.11 0.08 0.09 0.13 0.20
  0.57 0.69 0.62 0.49 0.30
non-pTau IgM    −0.62 −0.08 0.05 0.24
   0.0002 0.66 0.81 0.20
pTau IgM     0.23 −0.05 −0.13
    0.22 0.78 0.50
  1. Correlations in pooled data from all subjects are shown as Spearman’s rho values (top line) and their associated p-values (bottom line). The pTau IgM and non-pTau IgM ratios were negatively correlated, as were global cognitive functioning scores and the non-pTau IgG ratio. Subject age was positively associated with the non-pTau IgG ratio. (NFT = neurofibrillary tangles; pTau IgG = ratio of IgG binding to tau 196-207 phosphorylated at Serine-199 and Serine-202; non-pTau IgG = ratio of IgG binding to non-phosphorylated tau 196-207; pTau IgM = ratio of IgM binding to tau 196-207 phosphorylated at Serine-199 and Serine-202; non-pTau IgM = ratio of IgM binding to non-phosphorylated tau 196-207)