Specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and Alzheimer’s disease subjects: an exploratory study

Table 2 Correlations between tau antibody binding ratios, subject age, cognitive scores, and NFT counts using all study subjects

	pTau IgG	non-pTau IgM	pTau IgM	Age	Global Cognition	NFT counts
Non-pTau IgG	−0.14	−0.01	0.12	0.55	−0.50	0.14
Non-pTau IgG	0.47	0.95	0.51	0.002	0.005	0.46
pTau IgG		−0.11	0.08	0.09	0.13	0.20
pTau IgG		0.57	0.69	0.62	0.49	0.30
non-pTau IgM			−0.62	−0.08	0.05	0.24
non-pTau IgM			0.0002	0.66	0.81	0.20
pTau IgM				0.23	−0.05	−0.13
pTau IgM				0.22	0.78	0.50

Correlations in pooled data from all subjects are shown as Spearman’s rho values (top line) and their associated p-values (bottom line). The pTau IgM and non-pTau IgM ratios were negatively correlated, as were global cognitive functioning scores and the non-pTau IgG ratio. Subject age was positively associated with the non-pTau IgG ratio. (NFT = neurofibrillary tangles; pTau IgG = ratio of IgG binding to tau 196-207 phosphorylated at Serine-199 and Serine-202; non-pTau IgG = ratio of IgG binding to non-phosphorylated tau 196-207; pTau IgM = ratio of IgM binding to tau 196-207 phosphorylated at Serine-199 and Serine-202; non-pTau IgM = ratio of IgM binding to non-phosphorylated tau 196-207)

ISSN: 2047-9158