Table 3 Relationships between clinical features of patients and single SNPs

n

143

78

56

9

79

56

8

62

67

14

64

66

13

H&Y stage^b

2.0 ± 1.0

2.0 ± 1.5

2.0 ± 1.0

3.0 ± 0.5

0.007**

2.0 ± 1.5

2.0 ± 1.0

2.8 ± 0.5

0.01*

2.5 ± 1.0

2.0 ± 1.0

2.0 ± 0.8

0.07

2.5 ± 1.0

2.0 ± 1.0

2.0 ± 0.8

0.09

Age onset (years)^a

59.2 ± 9.2

60.7 ± 9.2

57.5 ± 9.4

57.3 ± 5.6

0.01*

60.7 ± 9.2

57.6 ± 9.4

56.8 ± 5.7

0.01*

59. 5 ± 9.5

58.828.6

60.3 ± 10.6

0.80

59.6 ± 9. 5

58.6 ± 8.6

60.8 ± 10.9

0.89

Disease duration (years)^b

6.0 ± 5.0

6.0 ± 4.0

6.0 ± 5.8

9.0 ± 7.5

0.005**

6.0 ± 4.0

6.0 ± 6.0

8.5 ± 9.5

0.005**

6.0 ± 5.3

6.0 ± 5.0

7.5 ± 7.3

0.73

6.0 ± 5.0

6.0 ± 5.0

8.0 ± 8.5

0.75

LED (mg)^a

448.8 ± 327.4

386.2 ± 287.5

496.8 ± 358.0

693.2 ± 322.6

0.005**

389.5 ± 287.2

497.7 ± 358.5

692.4 ± 344.8

0.007**

475.3 ± 399.2

425.0 ± 241.7

445.5 ± 346.5

0.56

469.7 ± 396.5

435.0 ± 243.6

416.4 ± 342.2

0.59

Wearing-off (yes, %)

43 (30.1)

18 (23.1)

19 (33.9)

6 (66. 7)

0.008**

18 (22. 8)

20 (35.7)

5 (65.1)

0.009**

20 (32.3)

17 (25.4)

6 (42.9)

0.94

20 (31.3)

18 (27.3)

5 (38.5)

0.87

Dyskinesia (yes, %)^b

18 (12.6)

7 (9.0)

9 (16.1)

2 (22.2)

0.12

7 (8.9)

9 (16.1)

2 (25.0)

0.09

8 (12.9)

7 (10. 5)

3 (21.4)

0.76

8 (12.5)

7 (10.6)

3 (23.1)

0.67

UPDRS Part I score ^b

2.0 ± 3.0

2.0 ± 3.0

3.0 ± 3.0

2.0 ± 3.0

0.92

2.0 ± 3.0

3.0 ± 3.0

2.0 ± 3.5

0.91

2.0 ± 3.0

2.0 ± 3.0

3.0 ± 3.0

0.41

2.0 ± 4.0

2.0 ± 3.0

3.0 ± 3.0

0.31

UPDRS Part II score ^b

8.0 ± 7.0

8.5 ± 9.0

8.0 ± 7.3

13.0 ± 10.0

0.002**

8.0 ± 9.0

8.0 ± 6.8

13.0 ± 7.8

0.02*

8.0 ± 7.0

8.0 ± 8.0

11.0 ± 7.3

0.48

8.0 ± 7.0

9.0 ± 7.0

9.0 ± 7.5

0.70

UPDRS Part III score ^a

24.7 ± 12.1

25.9 ± 11.9

21.8 ± 11.6

32. 8 ± 12.3

0.01*

25.8 ± 11.9

22.4 ± 12.1

31.0011.9

0.06

25.3 ± 12.3

24.2 ± 12.1

24.6 ± 11.6

0.82

24.8 ± 12.3

24.4 ± 12.3

26.2 ± 10.3

0.96

UPDRS Part IV score ^b

3.0 ± 2.0

3.0 ± 2.0

2.0 ± 3.0

5.0 ± 3.0

0.10

3.0 ± 2.0

2.0 ± 3.8

4.5 ± 4.0

0.13

3.0 ± 4.0

2.0 ± 3.0

3.0 ± 2.0

0.98

3.0 ± 4.0

2.5 ± 3.0

3.0 ± 2.0

0.96

UPDRS total score^a

40.0 ± 17.7

41.0 ± 17.4

36.3 ± 16.5

54.8 ± 20.2

0.006**

40.8 ± 17.3

37.1 ± 17.3

52.0 ± 19.7

0.04*

40.7 ± 18.4

38.8 ± 17.4

42.6 ± 15.8

0.79

40.2 ± 18.8

39.0 ± 17.1

44.1 ± 15.5

0.81

NMS score^b

6.0 ± 6.0

6.0 ± 6.0

6.0 ± 4.8

7.0 ± 9.5

0.60

6.0 ± 6.0

6.5 ± 4.8

6.5 ± 10.8

0.68

7.0 ± 6.3

6.0 ± 6.0

6.5 ± 5.5

0.57

7.0 ± 7.8

6.0 ± 5.3

6.0 ± 6.0

0.38

HAMA score^b

4.0 ± 6.0

4.0 ± 6.0

5.0 ± 4.5

4.0 ± 14.0

0.48

4.0 ± 6.0

5.0 ± 4.8

4.5 ± 13.3

0.40

5.0 ± 6.0

4.0 ± 4.0

6.0 ± 7.0

0.85

5.0 ± 6.0

4.0 ± 4.0

6.0 ± 6.0

0.93

HAMD score^b

3.0 ± 4.0

2.0 ± 5.0

4.0 ± 4.0

4.0 ± 6.0

0.40

2.0 ± 5.0

4.0 ± 4.0

3.0 ± 6.5

0.20

2.0 ± 6.3

3.0 ± 4.0

2.0 ± 3.8

0.14

2.0 ± 7.0

3.0 ± 4.0

2.0 ± 2.0

0.41

MMSE score^b

28.0 ± 3.0

28.0 ± 3.0

28.0 ± 3.0

27.0 ± 4.0

0.49

28.0 ± 3.0

28.0 ± 3.0

27.5 ± 3.0

0.54

28.0 ± 3.0

28.0 ± 3.0

28.0 ± 3.5

0.12

28.0 ± 3.0

28.0 ± 3.0

28.0 ± 3.5

0.13