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Table 1 Meta-analysis studies for cognitive training in healthy elders, MCI and AD patients

From: The role of cognitive activity in cognition protection: from Bedside to Bench

Reference

Participants

Training

Trials

Positive outcomes

Negative outcomes

Lampit, et al., 2014 [19]

Healthy elders

Computerized cognitive training

51

Overall effect; nonverbal, verbal and working memory; processing speed

EF and attention

Toril, P. et al., 2014 [200]

Healthy elders

Vedio game training

20

Reaction time, attention, memory, and global cognition

EF

Kelly, ME et al., 2014 [192]

Healthy elders

Memory-based intervention/diverse stimulations.

31

Executive function/global cognition—compared with active control

Memory/subjective cognition—compared with no training group

WM,recall, recognition

Recall, attention

Papp, K. et al., 2009 [201]

Healthy elders

Multi-domain training

10

All outcome measuresc

-

Li, H. et al., 2011 [202]

MCI

Multi-domain training

17

Overall cognition, self-ratings, EM, WM, EF

SM, PS, attention, VS

Martin, M. et al., 2011 [203]

Healthy elders

Multi-domain training

11

Immediate recalla

-

6

Delayed recalla

-

2

-

VS

5

-

Short-term memory

1

EFa

-

Bahar-F. et al., 2013 [204]

AD + VD

Multi-domain training

11

-

Any reported outcomes

Aquirre, E . et al., 2013 [205]

Dementia b

Cognitive and social function

7

ADAS-Cog

-

Sitzer, DI. et al., 2006 [206]

AD

At least one domain cognitive function

17

Overall cognitive ability

-

Woods, B. et al., 2012 [207]

Dementia b

Cognitive stimulation

7

ADAS-Cog

-

  1. EF executive function, WM working memory, MCI mild cognitive impairment, EM episodic memory, PS processing speed, VS visual-spatial ability, VD vascular dementia
  2. aImprovements observed did not exceed the improvement in the active control condition
  3. bAlzheimer’s disease, vascular dementia mixed Alzheimer’s and vascular dementia, other types of dementia. ADAS-Cog was applied only in AD patients
  4. cSignificant but negligible