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Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis

Fig. 1

Experimental design and time course. Diagram illustrates the time course of the overall experiment related to EAE, pre-symptom (EAE) and peak symptom (both EAE and EAE + PEG-treated) groups. In addition, the time points when the HRP-exclusion assay was conducted are illustrated: at pre-symptom (day 8 post-induction) and at peak symptom (Day 28 post-induction), with or without PEG treatment. Behavioral analysis was conducted daily and the average time of onset of symptoms, and the average time of reaching peak symptoms for both the EAE and the EAE + PEG group are illustrated. In the EAE + PEG group, PEG treatment was carried out for the entire period of study starting on the day of induction, as indicated in the diagram. Tissue samples for HRP testing were extracted for 4 different groups: healthy controls, pre-symptom EAE mice, peak symptom EAE mice and PEG-treated EAE mice

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Translational Neurodegeneration

ISSN: 2047-9158

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