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Table 1 Changes in clinical scales pre and post treatment

From: Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait

 

Baseline

Post treatment

Post washout

 

Mean

SD

Mean

SD

Mean

SD

FOGQ

12.50

2.95

12.10

3.11

13.10

2.64

CGI

3.60

1.26

3.00

1.49

4.00

1.33

DGI

19.70

2.63

19.60

4.35

19.50

5.38

Tinetti

23.10

4.65

23.90

4.31

25.00

3.33

FES

31.40

19.74

23.60

16.06

24.00

13.05

PDQ39

26.40

17.41

22.31

12.83

n/a

n/a

UPDRS I

2.50

3.06

2.10

2.56

1.78

2.05

UPDRS II

16.10

5.26

15.40

5.58

15.56

6.67

UPDRS III

22.80

9.95

21.70

10.57

23.90

9.78

UPDRS total

41.40

14.66

39.20

15.65

42.22

15.63

  1. Data correspond to scores on clinical scales for gait, balance, freezing of gait, falls, Parkinson’s symptoms, and quality of life. For all scales lower is better except for the Tinnetti
  2. FOG-Q Freezing of Gait Questionnaire, CGI Clinical Global Impression, DGI Dynamic Gait Index, Tinnetti Gait and Balance, FES Falls Efficacy Scale, PDQ-39 Parkinson’s Disease Questionnaire (quality of life measure), UPDRS (Unified Parkinson’s Disease Rating Scale), Part I (Mentation, Behavior, Mood), Part II (Activities of Daily Living), Part III (Motor), Part IV (Complications from therapy)