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Table 1 Therapeutic effects of traditional treatments and stem cells-based therapies for AD

From: Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment

Therapeutic effects Chemical treatments Stem-cells based therapies
Neuron replacement None ESCs
NSCs
MSCs
iPSCs
iNPCs
Aβ’s reduction Solanezumab (clinical trials failed) NSCs
Bapineuzumab (clinical trials failed) MSCs
Semagacestat (clinical trials failed)  
Neuron protective/neurotrophic action Memantine MSCs
Donepezl
Tacrine
Galanthamine
Rivastigmine
Huperzine A
N-acetyl-L-cysteine
Immune modulating Nonsteroidalantiinflammatory drugs MSCs