Table 1 Therapeutic effects of traditional treatments and stem cells-based therapies for AD
From: Direct reprogramming of induced neural progenitors: a new promising strategy for AD treatment
Therapeutic effects | Chemical treatments | Stem-cells based therapies |
|---|---|---|
Neuron replacement | None | ESCs |
NSCs | ||
MSCs | ||
iPSCs | ||
iNPCs | ||
Aβ’s reduction | Solanezumab (clinical trials failed) | NSCs |
Bapineuzumab (clinical trials failed) | MSCs | |
Semagacestat (clinical trials failed) | Â | |
Neuron protective/neurotrophic action | Memantine | MSCs |
Donepezl | ||
Tacrine | ||
Galanthamine | ||
Rivastigmine | ||
Huperzine A | ||
N-acetyl-L-cysteine | ||
Immune modulating | Nonsteroidalantiinflammatory drugs | MSCs |