Figure 1From: Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s diseaseThe effect of chronic hypoxia on AD. Hypoxia increases the β and γ cleavage of APP by demethylation in promoter CpG islands of APP, PS1, and BACE1. In addition, chronic hypoxia reduces the expression of NEP by up-regulating histone methyltransferase and histone deacetylase. All these contribute to the deposition of Aβ and AD pathogenesis.Back to article page