Figure 2

Neuropathological mechanisms possibly involved in tauopathies and expected tracking of tau spreading by imaging agents in rodent models. a) Pathological events (blue box) that contribute to tau hypherphosphorylation (purple box), microtubule detachment (green box), aggregation of paired helical filaments (PHFs) containing β-sheet structures (yellow box) and formation of neurofibrillary tangles (NFTs) containing the binding pocket for tau tracers (red box); b) Expected progression of tau pathology as shown by tau imaging agents based on previous findings in AD-like mouse models using immunohistochemistry. The image represents a coronal view of a T1-weighted mouse brain structural magnetic resonance imaging (MRI) image at bregma -2.88 mm.