Figure 1
From: Neurodegenerative changes initiated by presynaptic dysfunction
A hypothetical diagram showing enlarged presynaptic nerve terminals in SNAP-25 mutant mice. Normal presynaptic nerve terminals with uniform distribution of vesicles were observed in wild type mice while abnormally enlarged presynaptic nerve terminals with condensed synaptic vesicles and predominant localization of αSyn proteins in the periactive zones were found in SNAP-25 mutant mice, suggesting that SNARE dysfunction leads to presynaptic accumulation of endogenous αSyn and perturbations to the finely-tuned balance between exocytosis and endocytosis.