Figure 1

The Aβ-targeting strategies based on the Aβ cascade hypothesis. The processing of APP and the production, degradation of Aβ are illustrated and the therapeutic potential of targets are indicated with vertical arrows marked by alphabet: A, α-secretase activators; B, β-secretase inhibitors; C, γ-secretase inhibitors/modulators; D, immunotherapy; E, Aβ-aggregation inhibitors; F, Aβ-degradation activators. Modified and reproduced with permission from Yang et al. (2012) and see reference[2] for further details.