Figure 4

Effects of curcumin on the altered phosphorylation of Bcl-2 and interactions of Bcl-2 with Bax. (A) Effects of curcumin on the increased phosphorylation of Bcl-2 induced by MPTP in SNc. Western blot probed with antibodies to phosphorylated Bcl-2 (p-Bcl-2, Ser87) and Bcl-2. Bands corresponding to p-Bcl-2 and Bcl-2 were scanned and the intensities were represented as folds vs. saline groups. Data are expressed as mean ± SD (n = 6). ^aP < 0.05 vs. respective saline, ^bP < 0.05 vs. MPTP groups. (B) Co-immunoprecipitation analysis of interactions between Bcl-2 and Bax. Bands corresponding to Bax and Bcl-2 were scanned and the intensities were represented as folds vs. saline groups. Data are expressed as mean ± SD. ^aP < 0.05 vs. respective saline, ^bP < 0.05 vs. MPTP groups. (n = 6 mice).