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Figure 4 | Translational Neurodegeneration

Figure 4

From: Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease through suppressing mitochondria dysfunction

Figure 4

Effects of curcumin on the altered phosphorylation of Bcl-2 and interactions of Bcl-2 with Bax. (A) Effects of curcumin on the increased phosphorylation of Bcl-2 induced by MPTP in SNc. Western blot probed with antibodies to phosphorylated Bcl-2 (p-Bcl-2, Ser87) and Bcl-2. Bands corresponding to p-Bcl-2 and Bcl-2 were scanned and the intensities were represented as folds vs. saline groups. Data are expressed as mean ± SD (n = 6). aP < 0.05 vs. respective saline, bP < 0.05 vs. MPTP groups. (B) Co-immunoprecipitation analysis of interactions between Bcl-2 and Bax. Bands corresponding to Bax and Bcl-2 were scanned and the intensities were represented as folds vs. saline groups. Data are expressed as mean ± SD. aP < 0.05 vs. respective saline, bP < 0.05 vs. MPTP groups. (n = 6 mice).

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