Skip to main content

Articles

Page 6 of 10

  1. Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by dopaminergic nigrostriatal neuron loss and brain accumulation of Lewy bodies, protein aggregates mainly compos...

    Authors: Edoardo Parrella, Arianna Bellucci, Vanessa Porrini, Marina Benarese, Annamaria Lanzillotta, Gaia Faustini, Francesca Longhena, Giulia Abate, Daniela Uberti and Marina Pizzi
    Citation: Translational Neurodegeneration 2019 8:16
  2. Erythrocytes are a major source of peripheral α-synuclein (α-Syn). The goal of the current investigation is to evaluate erythrocytic total, oligomeric/aggregated, and phosphorylated α-Syn species as biomarkers...

    Authors: Chen Tian, Genliang Liu, Liyan Gao, David Soltys, Catherine Pan, Tessandra Stewart, Min Shi, Zhiying Xie, Na Liu, Tao Feng and Jing Zhang
    Citation: Translational Neurodegeneration 2019 8:15
  3. Few studies have investigated the effects of blood glucose (BG) on cognitive function in community-dwelling elderly individuals carrying the apolipoprotein E (APOE) ε3 allele.

    Authors: Qi Qiu, Xiang Lin, Lin Sun, Min-jie Zhu, Tao Wang, Jing-hua Wang, Guan-jun Li, Shi-fu Xiao and Xia Li
    Citation: Translational Neurodegeneration 2019 8:12
  4. IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with P...

    Authors: Franziska Hopfner, Stefanie H. Müller, Dagmar Steppat, Joanna Miller, Nele Schmidt, Klaus-Peter Wandinger, Frank Leypoldt, Daniela Berg, Andre Franke, Wolfgang Lieb, Lukas Tittmann, Monika Balzer-Geldsetzer, Simon Baudrexel, Richard Dodel, Ruediger Hilker-Roggendorf, Elke Kalbe…
    Citation: Translational Neurodegeneration 2019 8:11
  5. Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disease with fast progression. ALS has heavy genetic components in which a series of genetic mutations have been identified. In 2013, Mutat...

    Authors: Cheng Cheng, Kan Yang, Xinwei Wu, Yuefang Zhang, Shifang Shan, Aaron Gitler, Anirvan Ghosh and Zilong Qiu
    Citation: Translational Neurodegeneration 2019 8:13
  6. The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous ...

    Authors: José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García-Taboada, Manuel Guzmán, Eduardo Muñoz and Ismael Galve-Roperh
    Citation: Translational Neurodegeneration 2019 8:9
  7. Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease (AD), while how to initiate early cognitive stimulation is unclear. Given that the immature bra...

    Authors: Enjie Liu, Qiuzhi Zhou, Ao-Ji Xie, Mengzhu Li, Shujuan Zhang, Hezhou Huang, Zhenyu Liuyang, Yali Wang, Bingjin Liu, Xiaoguang Li, Dongsheng Sun, Yuping Wei, Xiaochuan Wang, Qun Wang, Dan Ke, Xifei Yang…
    Citation: Translational Neurodegeneration 2019 8:8
  8. Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson’s disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD. Recent studies...

    Authors: Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao and Gang Hu
    Citation: Translational Neurodegeneration 2019 8:7
  9. Gastrointestinal dysfunction can affect Parkinson’s disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the...

    Authors: Lucia Rota, Carolina Pellegrini, Laura Benvenuti, Luca Antonioli, Matteo Fornai, Corrado Blandizzi, Antonino Cattaneo and Emanuela Colla
    Citation: Translational Neurodegeneration 2019 8:5
  10. Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Le...

    Authors: Zhi Dong Zhou, Thevapriya Selvaratnam, Ji Chao Tristan Lee, Yin Xia Chao and Eng-King Tan
    Citation: Translational Neurodegeneration 2019 8:6
  11. Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease (AD) have not been fully clarified. 5-Hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) is a variable number ta...

    Authors: Grazia D’Onofrio, Francesco Panza, Daniele Sancarlo, Michele Lauriola, Mariangela P. Dagostino, Giulia Paroni, Madia Lozupone, Antonio Mangiacotti, Paola Bisceglia, Carolina Gravina, Maria Urbano, Filomena Addante, Francesco Paris, Leandro Cascavilla, Antonio Greco and Davide Seripa
    Citation: Translational Neurodegeneration 2019 8:4
  12. Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (Lewy bodies) within some remaining neurons in the substantia nigra. Recently, a...

    Authors: Shen-zhao Lu, Yong-shun Guo, Pei-zhou Liang, Shu-zhen Zhang, Shu Yin, Yan-qing Yin, Xiao-min Wang, Fei Ding, Xiao-song Gu and Jia-wei Zhou
    Citation: Translational Neurodegeneration 2019 8:3
  13. SOD1 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) in non-Caucasian patients. Detailed natural history profiles of SOD1-mutant patients will be beneficial for the strategy and interpr...

    Authors: Lu Tang, Yan Ma, Xiao-lu Liu, Lu Chen and Dong-sheng Fan
    Citation: Translational Neurodegeneration 2019 8:2

    The Correction to this article has been published in Translational Neurodegeneration 2019 8:10

  14. Parkinson’s Disease (PD) with mild cognitive impairment (MCI) (PD-MCI) represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia. Althoug...

    Authors: Mauro Adenzato, Rosa Manenti, Ivan Enrici, Elena Gobbi, Michela Brambilla, Antonella Alberici, Maria Sofia Cotelli, Alessandro Padovani, Barbara Borroni and Maria Cotelli
    Citation: Translational Neurodegeneration 2019 8:1
  15. Alzheimer’s disease (AD) is a fatal disease that threatens the quality of life of an aging population at a global scale. Various hypotheses on the etiology of AD have been developed over the years to guide eff...

    Authors: Hongmei Li, Chia-Chen Liu, Hui Zheng and Timothy Y. Huang
    Citation: Translational Neurodegeneration 2018 7:34
  16. In the original publication of this article [1] surname of the first author is wrong.

    Authors: Dan Zheng, Wei Xia, Zhong Quan Yi, Pan Wen Zhao, Jian Guo Zhong, Hai Cun Shi, Hua Liang Li, Zhen Yu Dai and Ping Lei Pan
    Citation: Translational Neurodegeneration 2018 7:33

    The original article was published in Translational Neurodegeneration 2018 7:26

  17. Neuron-microglia communication plays a crucial role in the motor neurons (MNs) death in amyotrophic lateral sclerosis (ALS). Neurons can express chemokine (C-X3-C motif) ligand 1 (CX3CL1), which mediates micro...

    Authors: Jingjing Zhang, Yufei Liu, Xinyao Liu, Song Li, Cheng Cheng, Sheng Chen and Weidong Le
    Citation: Translational Neurodegeneration 2018 7:35
  18. Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease (PD) treatment, but its effectiveness on Chinese patients is unclear. This study aimed to evaluate the efficacy and safety of rasagili...

    Authors: Zhenxin Zhang, Jian Wang, Shengdi Chen, Chunfeng Liu, Baorong Zhang, Rong Peng, Shenggang Sun, Xiangru Sun, Gang Zhao, Qiumin Qu, Yansheng Li, Suiqiang Zhu, Xiaoping Pan, Ming Shao and Yanping Wang
    Citation: Translational Neurodegeneration 2018 7:32
  19. The TANK-Binding Kinase 1 (TBK1) gene has recently been identified as the third or fourth most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The aim of this study was to...

    Authors: Bin Jiao, Qiying Sun, Zhenhua Yuan, Junling Wang, Lin Zhou, Xinxiang Yan, Beisha Tang and Lu Shen
    Citation: Translational Neurodegeneration 2018 7:31
  20. Amyotrophic lateral sclerosis (ALS) is currently an incurable disease without highly effective pharmacological treatments. The peptide drug GM604 (GM6 or Alirinetide) was developed as a candidate ALS therapy, ...

    Authors: William R. Swindell, Krzysztof Bojanowski, Mark S. Kindy, Raymond M. W. Chau and Dorothy Ko
    Citation: Translational Neurodegeneration 2018 7:30

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:24

  21. Resting-state functional magnetic resonance imaging studies using a regional homogeneity (ReHo) method have reported that amnestic mild cognitive impairment (aMCI) was associated with abnormalities in local fu...

    Authors: Dan Zheng, Wei Xia, Zhong Quan Yi, Pan Wen Zhao, Jian Guo Zhong, Hai Cun Shi, Hua Liang Li, Zhen Yu Dai and Ping Lei Pan
    Citation: Translational Neurodegeneration 2018 7:26

    The Correction to this article has been published in Translational Neurodegeneration 2018 7:33

  22. Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles. Our laboratory recently demo...

    Authors: Antonella Tramutola, Chiara Lanzillotta, Eugenio Barone, Andrea Arena, Ilaria Zuliani, Luciana Mosca, Carla Blarzino, D. Allan Butterfield, Marzia Perluigi and Fabio Di Domenico
    Citation: Translational Neurodegeneration 2018 7:28
  23. Cell replacement therapy has been envisioned as a promising treatment for neurodegenerative diseases. Due to the ethical concerns of ESCs-derived neural progenitor cells (NPCs) and tumorigenic potential of iPS...

    Authors: Kangmu Ma, Xiaobei Deng, Xiaohuan Xia, Zhaohuan Fan, Xinrui Qi, Yongxiang Wang, Yuju Li, Yizhao Ma, Qiang Chen, Hui Peng, Jianqing Ding, Chunhong Li, Yunlong Huang, Changhai Tian and Jialin C. Zheng
    Citation: Translational Neurodegeneration 2018 7:29
  24. Individuals with subjective memory complaints (SMC) feature a higher risk of cognitive decline and clinical progression of Alzheimer’s disease (AD). However, the pathological mechanism underlying SMC remains u...

    Authors: Kaicheng Li, Xiao Luo, Qingze Zeng, Yeerfan Jiaerken, Xiaojun Xu, Peiyu Huang, Zhujing Shen, Jingjing Xu, Chao Wang, Jiong Zhou and Min-Ming Zhang
    Citation: Translational Neurodegeneration 2018 7:27
  25. Circadian rhythms are oscillating physiological and behavioral changes governed by an internal molecular clock, and dysfunctions in circadian rhythms have been associated with ageing and various neurodegenerat...

    Authors: Xin Jiang, Tao Zhang, Haifang Wang, Tao Wang, Meiling Qin, Puhua Bao, Ruiqi Wang, Yuwei Liu, Hung-Chun Chang, Jun Yan and Jin Xu
    Citation: Translational Neurodegeneration 2018 7:24
  26. Rapid eye movement sleep behavior disorder (RBD) is associated with cognitive decline in early Parkinson’s disease (PD). However, the underlyling basis for this association remains unclear.

    Authors: Maowen Ba, Guoping Yu, Min Kong, Hui Liang and Ling Yu
    Citation: Translational Neurodegeneration 2018 7:22
  27. Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical p...

    Authors: Haichen Niu, Lingyu Shen, Tongzhou Li, Chao Ren, Sheng Ding, Lei Wang, Zhonghai Zhang, Xiaoyu Liu, Qiang Zhang, Deqin Geng, Xiujuan Wu and Haiying Li
    Citation: Translational Neurodegeneration 2018 7:25
  28. Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative brain disorder, which is the most common form of dementia. Intensive efforts have been made to find effective and safe treatment aga...

    Authors: Yuhuan Shi, Wanying Huang, Yu Wang, Rui Zhang, Lina Hou, Jianrong Xu, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang and Hao Wang
    Citation: Translational Neurodegeneration 2018 7:21
  29. Visinin-like protein-1 (VILIP-1) and chitinase-3-like protein 1 (CHI3L1 or YKL-40) in cerebrospinal fluid (CSF) are newly discovered markers indicating neuronal damage and microglial activation, respectively. ...

    Authors: Hua Zhang, Kok Pin Ng, Joseph Therriault, Min Su Kang, Tharick A. Pascoal, Pedro Rosa-Neto and Serge Gauthier
    Citation: Translational Neurodegeneration 2018 7:23
  30. Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD). Low-molecular-mass protein 7 (β5i) is...

    Authors: Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He and Ping-Yi Xu
    Citation: Translational Neurodegeneration 2018 7:19
  31. There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objectiv...

    Authors: Chao Gao, Stephen Smith, Michael Lones, Stuart Jamieson, Jane Alty, Jeremy Cosgrove, Pingchen Zhang, Jin Liu, Yimeng Chen, Juanjuan Du, Shishuang Cui, Haiyan Zhou and Shengdi Chen
    Citation: Translational Neurodegeneration 2018 7:18
  32. Amyotrophic lateral sclerosis (ALS) is a disease characterized by a progressive degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor imaging studies detected early white matter...

    Authors: Rodolfo G. Gatto, Manish Y. Amin, Daniel Deyoung, Matthew Hey, Thomas H. Mareci and Richard L. Magin
    Citation: Translational Neurodegeneration 2018 7:20
  33. The cardinal features of Parkinson’s disease (PD) are bradykinesia, rigidity and rest tremor. Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms. This study aims to...

    Authors: G. Du, P. Zhuang, M. Hallett, Y.-Q. Zhang, J.-Y. Li and Y.-J. Li
    Citation: Translational Neurodegeneration 2018 7:17
  34. The differential diagnosis of Parkinson’s disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to disc...

    Authors: Hai-Yan Zhou, Pei Huang, Qian Sun, Juan-Juan Du, Shi-Shuang Cui, Yun-Yun Hu, Wei-Wei Zhan, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan and Sheng-Di Chen
    Citation: Translational Neurodegeneration 2018 7:15
  35. Cognitive impairment is one of the non-motor symptoms in Parkinson’s disease (PD). In the present study, we aim to examine the cognitive function of non-demented Parkinson’s disease patients and compare the re...

    Authors: Ke Yang, Bo Shen, Da-ke Li, Ying Wang, Jue Zhao, Jian Zhao, Wen-Bo Yu, Zhen-yang Liu, Yi-lin Tang, Feng-tao Liu, Huan Yu, Jian Wang, Qi-hao Guo and Jian-jun Wu
    Citation: Translational Neurodegeneration 2018 7:16
  36. The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy ...

    Authors: Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li…
    Citation: Translational Neurodegeneration 2018 7:14
  37. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive...

    Authors: Qian-Qian Chen, Caroline Haikal, Wen Li, Ming-Tao Li, Zhan-You Wang and Jia-Yi Li
    Citation: Translational Neurodegeneration 2018 7:13
  38. The NIA-AA research framework proposes a biological definition of Alzheimer’s disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.

    Authors: S. Gauthier, H. Zhang, K. P. Ng, T.A. Pascoal and P. Rosa-Neto
    Citation: Translational Neurodegeneration 2018 7:12
  39. Deep Brain Stimulation (DBS) therapy for the treatment of Parkinson’s Disease (PD) is now a well-established option for some patients. Postoperative standardized programming processes can improve the level of ...

    Authors: Shengdi Chen, Guodong Gao, Tao Feng and Jianguo Zhang
    Citation: Translational Neurodegeneration 2018 7:11
  40. Brain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (D...

    Authors: Jia-Xing Cheng, Hong-Ying Zhang, Zheng-Kun Peng, Yao Xu, Hui Tang, Jing-Tao Wu and Jun Xu
    Citation: Translational Neurodegeneration 2018 7:10
  41. Brain 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer’s dementia (AD). However, the conver...

    Authors: Hai Rong Ma, Li Qin Sheng, Ping Lei Pan, Gen Di Wang, Rong Luo, Hai Cun Shi, Zhen Yu Dai and Jian Guo Zhong
    Citation: Translational Neurodegeneration 2018 7:9
  42. Parkinson’s disease (PD) is often accompanied by clinically identified depression. Providing effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to p...

    Authors: Alexandra M. Lesenskyj, Megan P. Samples, Jill M. Farmer and Christina R. Maxwell
    Citation: Translational Neurodegeneration 2018 7:8
  43. Animal models of exercise and Parkinson’s disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic fac...

    Authors: Mark A. Hirsch, Erwin E. H. van Wegen, Mark A. Newman and Patricia C. Heyn
    Citation: Translational Neurodegeneration 2018 7:7
  44. Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by patholo...

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas
    Citation: Translational Neurodegeneration 2018 7:6

    The Correction to this article has been published in Translational Neurodegeneration 2020 9:45

  45. Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized con...

    Authors: Bob G. Schultz, Denise K. Patten and Daniel J. Berlau
    Citation: Translational Neurodegeneration 2018 7:5
  46. Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly est...

    Authors: Belal Shohayeb, Mohamed Diab, Mazen Ahmed and Dominic Chi Hiung Ng
    Citation: Translational Neurodegeneration 2018 7:4
  47. Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of...

    Authors: Sandesh Panthi, Sumeet Manandhar and Kripa Gautam
    Citation: Translational Neurodegeneration 2018 7:3
  48. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extr...

    Authors: Xiaoguang Du, Xinyi Wang and Meiyu Geng
    Citation: Translational Neurodegeneration 2018 7:2

Affiliated with

Annual Journal Metrics

  • 2022 Citation Impact
    12.6 - 2-year Impact Factor
    10.9 - 5-year Impact Factor
    2.072 - SNIP (Source Normalized Impact per Paper)
    2.571 - SJR (SCImago Journal Rank)

    2023 Speed
    8 days submission to first editorial decision for all manuscripts (Median)
    111 days submission to accept (Median)

    2023 Usage
    767,289 downloads
    3,389 Altmetric mentions