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  2. Content type: Review

    Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles (NFTs) is a common feature in a wide range of neurodegenerative diseases known as tauopathies, which include Alzheime...

    Authors: Eduardo Rigon Zimmer, Antoine Leuzy, Venkat Bhat, Serge Gauthier and Pedro Rosa-Neto

    Citation: Translational Neurodegeneration 2014 3:6

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  3. Content type: Review

    Cognitive impairments are highly prevalent in Parkinson’s disease (PD) and can substantially affect a patient’s quality of life. These impairments remain difficult to manage with current clinical therapies, bu...

    Authors: Danielle K Murray, Matthew A Sacheli, Janice J Eng and A Jon Stoessl

    Citation: Translational Neurodegeneration 2014 3:5

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  5. Content type: Review

    Adult-onset autosomal dominant leukodystrophy (ADLD) is a progressive and fatal hereditary demyelination disorder characterized initially by autonomic dysfunction and loss of myelin in the central nervous syst...

    Authors: Shu-Ting Lin, Mary Y Heng, Louis J Ptáček and Ying-Hui Fu

    Citation: Translational Neurodegeneration 2014 3:4

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  6. Content type: Review

    Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory movement disorders, and has been approved by the United States Food and Drug Administration for treatment of dystonia. ...

    Authors: Wei Hu and Matt Stead

    Citation: Translational Neurodegeneration 2014 3:2

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  8. Content type: Research

    Autism spectrum disorder (ASD) is defined by standardized criteria of qualitative impairments in social interaction, qualitative impairments in communication, and restricted and stereotyped patterns of behavio...

    Authors: David A Geier, Brian S Hooker, Janet K Kern, Paul G King, Lisa K Sykes and Mark R Geier

    Citation: Translational Neurodegeneration 2013 2:25

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  9. Content type: Research

    Alzheimer’s disease (AD), the most common dementia, is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (NF...

    Authors: Shuk Wai Ho, Yuk Tung Chanel Tsui, Ting Ting Wong, Stanley Kwok-Kuen Cheung, William B Goggins, Lau Ming Yi, Kwok Kin Cheng and Larry Baum

    Citation: Translational Neurodegeneration 2013 2:24

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  10. Content type: Research

    Parkinson’s disease characterized by oxidative stress and mitochondrial damage in the pars compacta of substantia nigra remains a challenge to manage with an added disadvantage of side effects of L-levo dopa, ...

    Authors: Uvarajan Sampath and Vanisree Arambakkam Janardhanam

    Citation: Translational Neurodegeneration 2013 2:23

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  11. Content type: Review

    For the last 50 years, levodopa has been the cornerstone of Parkinson’s disease management. However, a majority of patients develop motor complications a few years after therapy onset. Deep brain stimulation h...

    Authors: Raja Mehanna and Eugene C Lai

    Citation: Translational Neurodegeneration 2013 2:22

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  13. Content type: Short report

    The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up...

    Authors: Nady Braidy, Wei-Ping Gai, Ying Hua Xu, Perminder Sachdev, Gilles J Guillemin, Xing-Mai Jiang, J William O Ballard, Martin P Horan, Zhi Ming Fang, Beng H Chong and DanielKam Yin Chan

    Citation: Translational Neurodegeneration 2013 2:20

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  15. Content type: Review

    This review is to analyze the role of National Natural Science Foundation of China (NSFC) on the development of basic research of Parkinson’s disease from 1990 to 2012. Data on the total number of projects and...

    Authors: Heqi Cao, Gang Chen and Erdan Dong

    Citation: Translational Neurodegeneration 2013 2:18

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  16. Content type: Review

    Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and abilities. Lo...

    Authors: Janet K Kern, David A Geier, Lisa K Sykes and Mark R Geier

    Citation: Translational Neurodegeneration 2013 2:17

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  17. Content type: Review

    α-Synucleinopathies are a subgroup of neurodegenerative diseases including dementia with Lewy bodies (DLB) and Parkinson’s disease (PD). Pathologically, these disorders can be characterized by the presence of ...

    Authors: Toru Yasuda, Yasuto Nakata, Chi-Jing Choong and Hideki Mochizuki

    Citation: Translational Neurodegeneration 2013 2:16

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  18. Content type: Review

    Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism...

    Authors: Shuting Zhang, Mingming Zhang, Fang Cai and Weihong Song

    Citation: Translational Neurodegeneration 2013 2:15

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  19. Content type: Research

    We aimed to evaluate the frequency of various types of B and T cells expressing CD21, CD32, and CD35 in multiple sclerosis (MS) clinical courses.

    Authors: Ali Zandieh, Maryam Izad, Mohammad Fakhri, Hamed Amirifard, Zahra Khazaeipour and Mohammad Hosein Harirchian

    Citation: Translational Neurodegeneration 2013 2:14

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  20. Content type: Review

    Parkinson’s disease (PD) is a synucleinopathy-induced chronic progressive neurodegenerative disorder, worldwide affecting about 5 million humans. As of yet, actual therapies are symptomatic, and neuroprotectiv...

    Authors: Johannes PJM de Munter, Chongsik Lee and Erik Ch Wolters

    Citation: Translational Neurodegeneration 2013 2:13

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  22. Content type: Research

    The short-term benefits of bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson’s disease (PD) are well documented, but long-term benefits are still uncertain. The aim of ...

    Authors: Dianyou Li, Chunyan Cao, Jing Zhang, Shikun Zhan, Shengdi Chen and Bomin Sun

    Citation: Translational Neurodegeneration 2013 2:11

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  23. Content type: Case report

    Lack of the fragile X mental retardation protein leads to Fragile X syndrome (FXS) while increased levels of FMR1 mRNA, as those observed in premutation carriers can lead to Fragile X- associated tremor ataxia sy...

    Authors: Dalyir I Pretto, Michael R Hunsaker, Christopher L Cunningham, Claudia M Greco, Randi J Hagerman, Stephen C Noctor, Deborah A Hall, Paul J Hagerman and Flora Tassone

    Citation: Translational Neurodegeneration 2013 2:10

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  24. Content type: Research

    To quantitatively evaluate severity of behavioral and psychological symptoms of dementia (BPSD) for vascular dementia (VD). Changes of 51 patients with VD in BPSD between the first and 24th week were assessed ...

    Authors: Wei-Dong Pan, Sohei Yoshida, Qian Liu, Chun-Lan Wu, Jun Wang, Jin Zhu and Ding-Fang Cai

    Citation: Translational Neurodegeneration 2013 2:9

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  30. Content type: Review

    Dementia with Lewy Bodies (DLB) was initially identified and confirmed primarily by pathology, but is soon to be incorporated into the Diagnostic and Statistical Manual criteria as a clinical disease entity. D...

    Authors: Yue Huang and Glenda Halliday

    Citation: Translational Neurodegeneration 2013 2:4

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  32. Content type: Research

    Many daily activities involve intrinsic or extrinsic goal-directed eye and hand movements. An extensive visuomotor coordination network including nigro-striatal pathways is required for efficient timing and po...

    Authors: Danya Muilwijk, Simone Verheij, Johan JM Pel, Agnita JW Boon and Johannes van der Steen

    Citation: Translational Neurodegeneration 2013 2:1

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  33. Content type: Research

    Both hyposmia and substania nigra (SN) hyperechogenicity on trascranial sonography (TCS) were risk markers for idiopathic Parkinson’s disease (PD), which was beneficial to the differential diagnosis of the dis...

    Authors: Wei Chen, Yu-Yan Tan, Yun-Yun Hu, Wei-Wei Zhan, Li Wu, Yue Lou, Xi Wang, Yi Zhou, Pei Huang, Yuan Gao, Qin Xiao and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2012 1:25

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  34. Content type: Review

    In addition to senile plaques and cerebral amyloid angiopathy, the hyperphosphorylation of tau protein and formation of intraneuronal neurofibrillary tangles (NFTs) represents another neuropathological hallmar...

    Authors: Yale Duan, Suzhen Dong, Feng Gu, Yinghe Hu and Zheng Zhao

    Citation: Translational Neurodegeneration 2012 1:24

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  35. Content type: Review

    Wilson disease is an autosomal recessive disorder of copper metabolism. Diagnosis depends primarily on clinical features, biochemical parameters and the presence of the Kayser-Fleischer ring. Genetic analysis ...

    Authors: Qin-Yun Dong and Zhi-Ying Wu

    Citation: Translational Neurodegeneration 2012 1:23

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  36. Content type: Research

    Our study aimed to investigate the prevalence of cognitive impairment(CI) and the associated risk factors among elderly people in Shanghai urban area, China.

    Authors: Jun-Peng Zhuang, Gang Wang, Qi Cheng, Li-Ling Wang, Rong Fang, Li-Hua Liu, Ran Xiong, Yu Zhang, Ya-Xing Gui, Wen-Yan Kang, Hui-Dong Tang and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2012 1:22

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  37. Content type: Review

    Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs mainly the memory and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau hyperphosphorylation are t...

    Authors: Yang Hong-Qi, Sun Zhi-Kun and Chen Sheng-Di

    Citation: Translational Neurodegeneration 2012 1:21

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  39. Content type: Research

    Amyloid beta peptide (Aβ) is the main component of extraneuronal senile plaques typical of Alzheimer’s disease (AD) brains. Although Aβ is produced by normal neurons, it is shown to accumulate in large amounts...

    Authors: Lin Zheng, Angel Cedazo-Minguez, Martin Hallbeck, Fredrik Jerhammar, Jan Marcusson and Alexei Terman

    Citation: Translational Neurodegeneration 2012 1:19

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  40. Content type: Review

    Alzheimer’s disease (AD) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits ...

    Authors: Suzhen Dong, Yale Duan, Yinghe Hu and Zheng Zhao

    Citation: Translational Neurodegeneration 2012 1:18

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  41. Content type: Research

    The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease (PD) is still poorly understood.

    Authors: Toni L Pitcher, Tracy R Melzer, Michael R MacAskill, Charlotte F Graham, Leslie Livingston, Ross J Keenan, Richard Watts, John C Dalrymple-Alford and Tim J Anderson

    Citation: Translational Neurodegeneration 2012 1:17

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  42. Content type: Research

    Curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly understood. The results of our r...

    Authors: Jing Pan, Hui Li, Jian-Fang Ma, Yu-Yan Tan, Qin Xiao, Jian-Qing Ding and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2012 1:16

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  43. Content type: Research

    Neurogenesis, including the proliferation, migration and differentiation of neural progenitor cells (NPCs), is impaired in HIV-1 associated dementia (HAD). We previously demonstrated HIV-1-infected macrophages...

    Authors: Yumei Wu, Qiang Chen, Hui Peng, Huanyu Dou, You Zhou, Yunlong Huang and Jialin C Zheng

    Citation: Translational Neurodegeneration 2012 1:15

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  45. Content type: Review

    Symptomatic treatment during the dementia stage of Alzheimer’s disease(AD) cannot delay or halt the progression of this disease. Therefore, prevention in the preclinical stage is likely the most effective way ...

    Authors: Serge Gauthier, Liyong Wu, Pedro Rosa-Neto and Jianping Jia

    Citation: Translational Neurodegeneration 2012 1:13

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  46. Content type: Research

    Focal dystonia is a neurological disorder characterized by unwanted muscle spasms. Blepharospasm is a focal dystonia producing an involuntary closure of the eyelid. Its etiology is unknown.

    Authors: Silvina G Horovitz, Anastasia Ford, Muslimah Ali Najee-ullah, John L Ostuni and Mark Hallett

    Citation: Translational Neurodegeneration 2012 1:12

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  48. Content type: Review

    Parkinson`s disease (PD) is a progressive, disabling neurodegenerative disorder with onset of motor and non-motor features. Both reduce quality of life of PD patients and cause caregiver burden. This review ai...

    Authors: Thomas Müller

    Citation: Translational Neurodegeneration 2012 1:10

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  50. Content type: Research

    Amyloid-β-protein (Aβ), the key component of senile plaques in Alzheimer's disease (AD) brain, is produced from amyloid precursor protein (APP) by cleavage of β-secretase and then γ-secretase. APP adaptor prot...

    Authors: Zhongcong Xie, Yuanlin Dong, Uta Maeda, Weiming Xia and Rudolph E Tanzi

    Citation: Translational Neurodegeneration 2012 1:8

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Translational Neurodegeneration

ISSN: 2047-9158

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