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  1. Language impairment is relatively common in Parkinson’s disease (PD), but not all PD patients are susceptible to language problems. In this study, we identified among a sample of PD patients those pre-disposed...

    Authors: Lin Liu, Xiao-Guang Luo, Chui-Liang Dy, Yan Ren, Yu Feng, Hong-Mei Yu, Hong Shang and Zhi-Yi He

    Citation: Translational Neurodegeneration 2015 4:2

    Content type: Research

    Published on:

  2. Nonmotor symptoms are common among patients with Parkinson’s disease (PD) and some may precede disease diagnosis.

    Authors: Honglei Chen, Edward J Zhao, Wen Zhang, Yi Lu, Rui Liu, Xuemei Huang, Anna J Ciesielski-Jones, Michele A Justice, Deborah S Cousins and Shyamal Peddada

    Citation: Translational Neurodegeneration 2015 4:1

    Content type: Research

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  3. A preferential dysfunction/loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) accounts for the main motor symptoms of Parkinson’s disease (PD), the most common degenerative movement di...

    Authors: Huaibin Cai, Guoxiang Liu, Lixin Sun and Jinhui Ding

    Citation: Translational Neurodegeneration 2014 3:27

    Content type: Review

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  4. Chronic levodopa (L-dopa) treatment in Parkinson’s disease (PD) is often associated with the development of motor complications, but the corresponding epidemiological data is rare in Chinese PD patients. The p...

    Authors: Wei Chen, Qin Xiao, Ming Shao, Tao Feng, Wei-Guo Liu, Xiao-Guang Luo, Xiao-Chun Chen, An-Mu Xie, Chun-Feng Liu, Zhen-Guo Liu, Yi-Ming Liu, Jian Wang and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2014 3:26

    Content type: Research

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  5. The transition metal copper enhances amyloid β aggregation and neurotoxicity, and in models of concomitant amyloid and tau pathology, copper also promotes tau aggregation. Since it is not clear if the effects ...

    Authors: Kellen Voss, Christopher Harris, Martina Ralle, Megan Duffy, Charles Murchison and Joseph F Quinn

    Citation: Translational Neurodegeneration 2014 3:24

    Content type: Research

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  6. Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple s...

    Authors: Kristi M Anderson, Katherine E Olson, Katherine A Estes, Ken Flanagan, Howard E Gendelman and R Lee Mosley

    Citation: Translational Neurodegeneration 2014 3:25

    Content type: Review

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  7. Mass spectrometry (MS)-based proteomics has developed into a battery of approaches that is exceedingly adept at identifying with high mass accuracy and precision any of the following: oxidative damage to prote...

    Authors: Ru-Jing Ren, Eric B Dammer, Gang Wang, Nicholas T Seyfried and Allan I Levey

    Citation: Translational Neurodegeneration 2014 3:23

    Content type: Review

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  8. Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with an exposed CMA-targeting motif to lysosomes for degradation and plays an important role in protein quality control and cellular h...

    Authors: Gang Wang and Zixu Mao

    Citation: Translational Neurodegeneration 2014 3:20

    Content type: Review

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  9. Mutant (MT) forms of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis—familial amyloidotic polyneuropathy (FAP). Until 20 years ago, FAP was thought to be an...

    Authors: Mitsuharu Ueda and Yukio Ando

    Citation: Translational Neurodegeneration 2014 3:19

    Content type: Review

    Published on:

  10. A significant number of children diagnosed with autism spectrum disorder suffer a loss of previously-acquired skills, suggesting neurodegeneration or a type of progressive encephalopathy with an etiological ba...

    Authors: Brian S Hooker

    Citation: Translational Neurodegeneration 2014 3:16

    Content type: Research

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    The Retraction Note to this article has been published in Translational Neurodegeneration 2014 3:22

  11. Progressive cognitive decline is a feature of Huntington’s disease (HD), an inherited neurodegenerative movement disorder. Comprehensive neuropsychological testing is the ‘gold standard’ to establish cognitive...

    Authors: Eng A Toh, Michael R MacAskill, John C Dalrymple-Alford, Daniel J Myall, Leslie Livingston, Sandy AD Macleod and Tim J Anderson

    Citation: Translational Neurodegeneration 2014 3:15

    Content type: Research

    Published on:

  12. Hemiballism-hemichorea (HB-HC) is commonly used to describe the basal ganglion dysfunction in non-ketotic hyperglycemic elderly patients. Here we report two elderly female patients with acute onset of involunt...

    Authors: Yuyan Tan, Xiaoyu Xin, Qin Xiao, Shengdi Chen, Li Cao and Huidong Tang

    Citation: Translational Neurodegeneration 2014 3:14

    Content type: Case report

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  13. Cardiovascular risk factors (CRF) were widely described as related to dementia. There are very few studies regarding this association in FTD. The objective of the study was to compare the frequency of CRF in o...

    Authors: Angel Golimstok, Nuria Cámpora, Juan I Rojas, María C Fernandez, Cristina Elizondo, Enrique Soriano and Edgardo Cristiano

    Citation: Translational Neurodegeneration 2014 3:13

    Content type: Research

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  14. Progress has been made in understanding the genetics and molecular biology of frontotemporal dementia (FTD). Targets for intervention have been identified, therapies are being developed, and clinical trials ar...

    Authors: Justin B Miller, Sarah J Banks, Gabriel C Léger and Jeffrey L Cummings

    Citation: Translational Neurodegeneration 2014 3:12

    Content type: Review

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  15. To evaluate the non-inferiority of pramipexole extended-release (ER) versus immediate-release (IR) in Chinese patients with Parkinson’s disease (PD) in a double-blind, randomized, parallel-group study.

    Authors: Ying Wang, Shenggang Sun, Suiqiang Zhu, Chunfeng Liu, Yiming Liu, Qing Di, Huifang Shang, Yan Ren, Changhong Lu, Mark Forrest Gordon, Nolwenn Juhel and Shengdi Chen

    Citation: Translational Neurodegeneration 2014 3:11

    Content type: Research

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  16. Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS) and retinal degeneration have been studied extensively and varying molecular mechanism...

    Authors: Shweta Modgil, Debomoy K Lahiri, Vijay L Sharma and Akshay Anand

    Citation: Translational Neurodegeneration 2014 3:9

    Content type: Review

    Published on:

  17. Alzheimer’s disease (AD) is the most common form of dementia. At the present time, however, AD still lacks effective treatments. Our recent studies showed that chronic treatment with anesthetic propofol attenu...

    Authors: Yiying Zhang, Haijun Shao, Yuanlin Dong, Celeste A Swain, Buwei Yu, Weiming Xia and Zhongcong Xie

    Citation: Translational Neurodegeneration 2014 3:8

    Content type: Research

    Published on:

  18. Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles (NFTs) is a common feature in a wide range of neurodegenerative diseases known as tauopathies, which include Alzheime...

    Authors: Eduardo Rigon Zimmer, Antoine Leuzy, Venkat Bhat, Serge Gauthier and Pedro Rosa-Neto

    Citation: Translational Neurodegeneration 2014 3:6

    Content type: Review

    Published on:

  19. Cognitive impairments are highly prevalent in Parkinson’s disease (PD) and can substantially affect a patient’s quality of life. These impairments remain difficult to manage with current clinical therapies, bu...

    Authors: Danielle K Murray, Matthew A Sacheli, Janice J Eng and A Jon Stoessl

    Citation: Translational Neurodegeneration 2014 3:5

    Content type: Review

    Published on:

  20. Adult-onset autosomal dominant leukodystrophy (ADLD) is a progressive and fatal hereditary demyelination disorder characterized initially by autonomic dysfunction and loss of myelin in the central nervous syst...

    Authors: Shu-Ting Lin, Mary Y Heng, Louis J Ptáček and Ying-Hui Fu

    Citation: Translational Neurodegeneration 2014 3:4

    Content type: Review

    Published on:

  21. Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory movement disorders, and has been approved by the United States Food and Drug Administration for treatment of dystonia. ...

    Authors: Wei Hu and Matt Stead

    Citation: Translational Neurodegeneration 2014 3:2

    Content type: Review

    Published on:

  22. Autism spectrum disorder (ASD) is defined by standardized criteria of qualitative impairments in social interaction, qualitative impairments in communication, and restricted and stereotyped patterns of behavio...

    Authors: David A Geier, Brian S Hooker, Janet K Kern, Paul G King, Lisa K Sykes and Mark R Geier

    Citation: Translational Neurodegeneration 2013 2:25

    Content type: Research

    Published on:

  23. Alzheimer’s disease (AD), the most common dementia, is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (NF...

    Authors: Shuk Wai Ho, Yuk Tung Chanel Tsui, Ting Ting Wong, Stanley Kwok-Kuen Cheung, William B Goggins, Lau Ming Yi, Kwok Kin Cheng and Larry Baum

    Citation: Translational Neurodegeneration 2013 2:24

    Content type: Research

    Published on:

  24. Parkinson’s disease characterized by oxidative stress and mitochondrial damage in the pars compacta of substantia nigra remains a challenge to manage with an added disadvantage of side effects of L-levo dopa, ...

    Authors: Uvarajan Sampath and Vanisree Arambakkam Janardhanam

    Citation: Translational Neurodegeneration 2013 2:23

    Content type: Research

    Published on:

  25. For the last 50 years, levodopa has been the cornerstone of Parkinson’s disease management. However, a majority of patients develop motor complications a few years after therapy onset. Deep brain stimulation h...

    Authors: Raja Mehanna and Eugene C Lai

    Citation: Translational Neurodegeneration 2013 2:22

    Content type: Review

    Published on:

  26. The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up...

    Authors: Nady Braidy, Wei-Ping Gai, Ying Hua Xu, Perminder Sachdev, Gilles J Guillemin, Xing-Mai Jiang, J William O Ballard, Martin P Horan, Zhi Ming Fang, Beng H Chong and DanielKam Yin Chan

    Citation: Translational Neurodegeneration 2013 2:20

    Content type: Short report

    Published on:

  27. This review is to analyze the role of National Natural Science Foundation of China (NSFC) on the development of basic research of Parkinson’s disease from 1990 to 2012. Data on the total number of projects and...

    Authors: Heqi Cao, Gang Chen and Erdan Dong

    Citation: Translational Neurodegeneration 2013 2:18

    Content type: Review

    Published on:

  28. Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and abilities. Lo...

    Authors: Janet K Kern, David A Geier, Lisa K Sykes and Mark R Geier

    Citation: Translational Neurodegeneration 2013 2:17

    Content type: Review

    Published on:

  29. α-Synucleinopathies are a subgroup of neurodegenerative diseases including dementia with Lewy bodies (DLB) and Parkinson’s disease (PD). Pathologically, these disorders can be characterized by the presence of ...

    Authors: Toru Yasuda, Yasuto Nakata, Chi-Jing Choong and Hideki Mochizuki

    Citation: Translational Neurodegeneration 2013 2:16

    Content type: Review

    Published on:

  30. Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism...

    Authors: Shuting Zhang, Mingming Zhang, Fang Cai and Weihong Song

    Citation: Translational Neurodegeneration 2013 2:15

    Content type: Review

    Published on:

  31. We aimed to evaluate the frequency of various types of B and T cells expressing CD21, CD32, and CD35 in multiple sclerosis (MS) clinical courses.

    Authors: Ali Zandieh, Maryam Izad, Mohammad Fakhri, Hamed Amirifard, Zahra Khazaeipour and Mohammad Hosein Harirchian

    Citation: Translational Neurodegeneration 2013 2:14

    Content type: Research

    Published on:

  32. Parkinson’s disease (PD) is a synucleinopathy-induced chronic progressive neurodegenerative disorder, worldwide affecting about 5 million humans. As of yet, actual therapies are symptomatic, and neuroprotectiv...

    Authors: Johannes PJM de Munter, Chongsik Lee and Erik Ch Wolters

    Citation: Translational Neurodegeneration 2013 2:13

    Content type: Review

    Published on:

  33. The short-term benefits of bilateral stimulation of the subthalamic nucleus (STN) in patients with advanced Parkinson’s disease (PD) are well documented, but long-term benefits are still uncertain. The aim of ...

    Authors: Dianyou Li, Chunyan Cao, Jing Zhang, Shikun Zhan, Shengdi Chen and Bomin Sun

    Citation: Translational Neurodegeneration 2013 2:11

    Content type: Research

    Published on:

  34. Lack of the fragile X mental retardation protein leads to Fragile X syndrome (FXS) while increased levels of FMR1 mRNA, as those observed in premutation carriers can lead to Fragile X- associated tremor ataxia sy...

    Authors: Dalyir I Pretto, Michael R Hunsaker, Christopher L Cunningham, Claudia M Greco, Randi J Hagerman, Stephen C Noctor, Deborah A Hall, Paul J Hagerman and Flora Tassone

    Citation: Translational Neurodegeneration 2013 2:10

    Content type: Case report

    Published on:

  35. To quantitatively evaluate severity of behavioral and psychological symptoms of dementia (BPSD) for vascular dementia (VD). Changes of 51 patients with VD in BPSD between the first and 24th week were assessed ...

    Authors: Wei-Dong Pan, Sohei Yoshida, Qian Liu, Chun-Lan Wu, Jun Wang, Jin Zhu and Ding-Fang Cai

    Citation: Translational Neurodegeneration 2013 2:9

    Content type: Research

    Published on:

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