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  1. Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson’s disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsoni...

    Authors: Usman Saeed, Jordana Compagnone, Richard I. Aviv, Antonio P. Strafella, Sandra E. Black, Anthony E. Lang and Mario Masellis

    Citation: Translational Neurodegeneration 2017 6:8

    Content type: Review

    Published on:

  2. A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently...

    Authors: Patrick Sweeney, Hyunsun Park, Marc Baumann, John Dunlop, Judith Frydman, Ron Kopito, Alexander McCampbell, Gabrielle Leblanc, Anjli Venkateswaran, Antti Nurmi and Robert Hodgson

    Citation: Translational Neurodegeneration 2017 6:6

    Content type: Review

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  3. It is increasingly clear that in addition to myelin disruption, axonal degeneration may also represent a key pathology in multiple sclerosis (MS). Hence, elucidating the mechanisms of axonal degeneration may n...

    Authors: Gary Leung, Melissa Tully, Jonathan Tang, Shengxi Wu and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:5

    Content type: Research

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  4. Neurodegeneration of Parkinson’s disease (PD) starts in an insidious manner, 30–50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, dur...

    Authors: Shu-Ying Liu, Piu Chan and A. Jon Stoessl

    Citation: Translational Neurodegeneration 2017 6:4

    Content type: Review

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  5. Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular componen...

    Authors: Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu and Lu Shen

    Citation: Translational Neurodegeneration 2017 6:3

    Content type: Review

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  6. Alzheimer’s Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (...

    Authors: Rong Fang, Shengxuan Ye, Jiangtao Huangfu and David P. Calimag

    Citation: Translational Neurodegeneration 2017 6:2

    Content type: Review

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  7. L-3, 4-Dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) is a major clinical complication in the treatment of Parkinson’s disease (PD). This debilitating side effect likely reflects aberrant compensator...

    Authors: Jing Pan and Huaibin Cai

    Citation: Translational Neurodegeneration 2017 6:1

    Content type: Review

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  8. Acute-onset neurodegenerative diseases in older patients are rare clinical cases, especially when the degeneration only affects specific regions of the nervous system. Several neurological disorders have been ...

    Authors: Alexander Schulz, Franziska Wagner, Martin Ungelenk, Ingo Kurth and Christoph Redecker

    Citation: Translational Neurodegeneration 2016 5:23

    Content type: Case report

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  9. Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of the common complications in patients with diabetes. Previous studies have showed that autophagy...

    Authors: Zhu-Fei Guan, Xiu-Ling Zhou, Xiao-Ming Zhang, Yu Zhang, Yan-Mei Wang, Qi-Lin Guo, Gang Ji, Guo-Feng Wu, Na-Na Wang, Hao Yang, Zhong-Yu Yu, Hou-Guang Zhou, Jing-Chun Guo and Ying-Chao Liu

    Citation: Translational Neurodegeneration 2016 5:22

    Content type: Research

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  10. Alzheimer’s disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment ag...

    Authors: Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun and Shengdi Chen

    Citation: Translational Neurodegeneration 2016 5:21

    Content type: Research

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  11. Amyloid plaques are pathological hallmarks of Alzheimer’s Disease (AD) and biomarkers such as cerebrospinal fluid (CSF) β-amyloid 1–42 (Aβ1-42) and amyloid positron emission tomographic (PET) imaging are impor...

    Authors: Maowen Ba, Min Kong, Xiaofeng Li, Kok Pin Ng, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2016 5:20

    Content type: Review

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  15. Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histoco...

    Authors: Li Chen, Mingshu Mo, Guangning Li, Luan Cen, Lei Wei, Yousheng Xiao, Xiang Chen, Shaomin Li, Xinling Yang, Shaogang Qu and Pingyi Xu

    Citation: Translational Neurodegeneration 2016 5:16

    Content type: Review

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  16. Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease (PD) from patients with non-Parkinsonian syndromes. Our previous study indicated that the ...

    Authors: Wenyan Kang, Fangyi Dong, Dunhui Li, Thomas J. Quinn, Shengdi Chen and Jun Liu

    Citation: Translational Neurodegeneration 2016 5:15

    Content type: Research

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  17. Parkinson’s disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and the formation of Lewy bodies ...

    Authors: Qingsong Hu and Guanghui Wang

    Citation: Translational Neurodegeneration 2016 5:14

    Content type: Review

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  19. Parkinson’s disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia an...

    Authors: Shengdi Chen, Piu Chan, Shenggang Sun, Haibo Chen, Baorong Zhang, Weidong Le, Chunfeng Liu, Guoguang Peng, Beisha Tang, Lijuan Wang, Yan Cheng, Ming Shao, Zhenguo Liu, Zhenfu Wang, Xiaochun Chen, Mingwei Wang…

    Citation: Translational Neurodegeneration 2016 5:12

    Content type: Review

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  20. Parkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder population. Parkinson’s disease dementia (PDD) is one of the most common non-motor manifestations in PD patients. No compr...

    Authors: Yaqian Xu, Jing Yang and Huifang Shang

    Citation: Translational Neurodegeneration 2016 5:11

    Content type: Review

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  21. Benign tremulous parkinsonism (BTP) is characterized by a prominent tremor that occurs both at rest and with action in conjunction with other mild features of parkinsonism. The progression of symptoms is typic...

    Authors: Wissam Deeb, Wei Hu, Leonardo Almeida, Addie Patterson, Daniel Martinez-Ramirez and Aparna Wagle Shukla

    Citation: Translational Neurodegeneration 2016 5:10

    Content type: Review

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  22. Fatigue, which is commonly observed in Parkinson’s disease (PD), can greatly reduce quality of life and is difficult to treat. We here aimed to investigate the prevalence and characteristics of fatigue among P...

    Authors: Rao Fu, Xiao-Guang Luo, Yan Ren, Zhi-Yi He and Hong Lv

    Citation: Translational Neurodegeneration 2016 5:9

    Content type: Research

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  23. China has more cases of Alzheimer’s disease (AD) than any other country in the world. As training to recognize and manage dementia is in its early stage, it is important to study clinicians’ current prescripti...

    Authors: Chun-Xia Ban, Shi-Fu Xiao, Xiang Lin, Tao Wang, Qi Qiu, Min-Jie Zhu and Xia Li

    Citation: Translational Neurodegeneration 2016 5:8

    Content type: Research

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  25. DJ-1 has been thought as a candidate biomarker for Parkinson’s disease (PD). It was found reduced in PD brains, CSF and saliva, although there were conflicting results. How DJ-1 expression may be regulated is ...

    Authors: Yuyan Tan, Li Wu, Dunhui Li, Xiaoli Liu, Jianqing Ding and Shengdi Chen

    Citation: Translational Neurodegeneration 2016 5:5

    Content type: Research

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  26. MicroRNAs (miRNAs) are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression. Measurements of miRNAs in cerebrospinal fluid (CSF) and blood have just started gaining...

    Authors: Sofie Sølvsten Sørensen, Ann-Britt Nygaard and Thomas Christensen

    Citation: Translational Neurodegeneration 2016 5:6

    Content type: Research

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  27. Levodopa and dopamine agonists are the main treatments for Parkinson’s disease (PD) in recent years. Increased drug dosages are linked to some severe side effects, one of which is impulse control disorders (IC...

    Authors: Xue-Ping Wang, Ming Wei and Qin Xiao

    Citation: Translational Neurodegeneration 2016 5:4

    Content type: Research

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  29. Brain-derived neurotrophic factor (BDNF) regulates a variety of biological processes predominantly via binding to the transmembrane receptor tyrosine kinase TrkB. It is a potential therapeutic target in numero...

    Authors: Chaoyang Liu, Chi Bun Chan and Keqiang Ye

    Citation: Translational Neurodegeneration 2016 5:2

    Content type: Review

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  31. Freezing of gait (FoG) is a common and debilitating condition in Parkinson’s disease (PD) associated with executive dysfunction. A subtype of FoG does not respond to dopaminergic therapy and may be related to ...

    Authors: Gonzalo J. Revuelta, Aaron Embry, Jordan J. Elm, Chris Gregory, Amy Delambo, Steve Kautz and Vanessa K. Hinson

    Citation: Translational Neurodegeneration 2015 4:24

    Content type: Short report

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  32. α–synuclein (α–syn) is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease (PD) and certain other neurodegenerative disorders. Recent studies have exp...

    Authors: Namratha Sastry, Wang Zheng, Guoxiang Liu, Helen Wang, Xi Chen, Michael Cai, Parth Contractor, Carmelo Sgobio, Lixin Sun, Chengsong Xie and Huaibin Cai

    Citation: Translational Neurodegeneration 2015 4:23

    Content type: Research

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  33. Common neurodegenerative diseases include Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). Transcranial magnetic stimulation (TMS) is a non...

    Authors: Zhen Ni and Robert Chen

    Citation: Translational Neurodegeneration 2015 4:22

    Content type: Review

    Published on:

  39. Parkinson’s disease (PD) is one of the most common neurodegenerative disorders of aging, characterized by the degeneration of dopamine neurons (DA neurons) in the substantial nigra, leading to the advent of bo...

    Authors: Fabin Han, Deborah Baremberg, Junyu Gao, Jing Duan, Xianjie Lu, Nan Zhang and Qingfa Chen

    Citation: Translational Neurodegeneration 2015 4:16

    Content type: Review

    Published on:

  40. Healthcare resource utilisation for Alzheimer’s disease (AD) in China is not well understood. This Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in u...

    Authors: Xin Yu, Shengdi Chen, Xiaochun Chen, Jianjun Jia, Chunhou Li, Cong Liu, Mondher Toumi and Dominique Milea

    Citation: Translational Neurodegeneration 2015 4:15

    Content type: Research

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  41. Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatme...

    Authors: Zhen Jiang, Wenzhang Wang, George Perry, Xiongwei Zhu and Xinglong Wang

    Citation: Translational Neurodegeneration 2015 4:14

    Content type: Review

    Published on:

  43. Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease (PD) and other movement disorders symptoms along with some psychiatric conditions. Over ...

    Authors: Daniel Martinez-Ramirez, Wei Hu, Alberto R. Bona, Michael S. Okun and Aparna Wagle Shukla

    Citation: Translational Neurodegeneration 2015 4:12

    Content type: Review

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  44. Wnt/β-catenin signal has been reported to exert cytoprotective effects in cellular models of several diseases, including Parkinson’s disease (PD). This study aimed to investigate the neuroprotective effects of...

    Authors: Lei Wei, Li Ding, Ming-shu Mo, Ming Lei, Limin Zhang, Kang Chen and Pingyi Xu

    Citation: Translational Neurodegeneration 2015 4:11

    Content type: Research

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  46. In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in micro...

    Authors: Fan Zhang, Bo Su, Chunyu Wang, Sandra L. Siedlak, Siddhartha Mondragon-Rodriguez, Hyoung-gon Lee, Xinglong Wang, George Perry and Xiongwei Zhu

    Citation: Translational Neurodegeneration 2015 4:9

    Content type: Research

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  48. Alzheimer’s disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cogni...

    Authors: Siqiang Lai, Min Zhang, Dongsheng Xu, Yiying Zhang, Lisha Qiu, Changhai Tian and Jialin Charlie Zheng

    Citation: Translational Neurodegeneration 2015 4:7

    Content type: Review

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  49. α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein funct...

    Authors: Huda Saleh, Ayeh Saleh, Hailan Yao, Jie Cui, Yong Shen and Rena Li

    Citation: Translational Neurodegeneration 2015 4:5

    Content type: Review

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  50. Voxel-based morphometry (VBM) using structural brain MRI has been widely used for the assessment of impairment in Alzheimer’s disease (AD), but previous studies in VBM studies on AD remain inconsistent.

    Authors: Wen-Ying Wang, Jin-Tai Yu, Yong Liu, Rui-Hua Yin, Hui-Fu Wang, Jun Wang, Lin Tan, Joaquim Radua and Lan Tan

    Citation: Translational Neurodegeneration 2015 4:6

    Content type: Research

    Published on:

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