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  1. Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative brain disorder, which is the most common form of dementia. Intensive efforts have been made to find effective and safe treatment aga...

    Authors: Yuhuan Shi, Wanying Huang, Yu Wang, Rui Zhang, Lina Hou, Jianrong Xu, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang and Hao Wang

    Citation: Translational Neurodegeneration 2018 7:21

    Content type: Research

    Published on:

  2. Visinin-like protein-1 (VILIP-1) and chitinase-3-like protein 1 (CHI3L1 or YKL-40) in cerebrospinal fluid (CSF) are newly discovered markers indicating neuronal damage and microglial activation, respectively. ...

    Authors: Hua Zhang, Kok Pin Ng, Joseph Therriault, Min Su Kang, Tharick A. Pascoal, Pedro Rosa-Neto and Serge Gauthier

    Citation: Translational Neurodegeneration 2018 7:23

    Content type: Research

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  3. Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD). Low-molecular-mass protein 7 (β5i) is...

    Authors: Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He and Ping-Yi Xu

    Citation: Translational Neurodegeneration 2018 7:19

    Content type: Research

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  4. There is an urgent need for developing objective, effective and convenient measurements to help clinicians accurately identify bradykinesia. The purpose of this study is to evaluate the accuracy of an objectiv...

    Authors: Chao Gao, Stephen Smith, Michael Lones, Stuart Jamieson, Jane Alty, Jeremy Cosgrove, Pingchen Zhang, Jin Liu, Yimeng Chen, Juanjuan Du, Shishuang Cui, Haiyan Zhou and Shengdi Chen

    Citation: Translational Neurodegeneration 2018 7:18

    Content type: Research

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  5. Amyotrophic lateral sclerosis (ALS) is a disease characterized by a progressive degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor imaging studies detected early white matter...

    Authors: Rodolfo G. Gatto, Manish Y. Amin, Daniel Deyoung, Matthew Hey, Thomas H. Mareci and Richard L. Magin

    Citation: Translational Neurodegeneration 2018 7:20

    Content type: Research

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  6. The cardinal features of Parkinson’s disease (PD) are bradykinesia, rigidity and rest tremor. Abnormal activity in the basal ganglia is predicted to underlie the mechanism of motor symptoms. This study aims to...

    Authors: G. Du, P. Zhuang, M. Hallett, Y.-Q. Zhang, J.-Y. Li and Y.-J. Li

    Citation: Translational Neurodegeneration 2018 7:17

    Content type: Research

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  7. The differential diagnosis of Parkinson’s disease (PD) and multiple system atrophy (MSA) remains a challenge, especially in the early stage. Here, we assessed the value of transcranial sonography (TCS) to disc...

    Authors: Hai-Yan Zhou, Pei Huang, Qian Sun, Juan-Juan Du, Shi-Shuang Cui, Yun-Yun Hu, Wei-Wei Zhan, Ying Wang, Qin Xiao, Jun Liu, Yu-Yan Tan and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2018 7:15

    Content type: Research

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  8. Cognitive impairment is one of the non-motor symptoms in Parkinson’s disease (PD). In the present study, we aim to examine the cognitive function of non-demented Parkinson’s disease patients and compare the re...

    Authors: Ke Yang, Bo Shen, Da-ke Li, Ying Wang, Jue Zhao, Jian Zhao, Wen-Bo Yu, Zhen-yang Liu, Yi-lin Tang, Feng-tao Liu, Huan Yu, Jian Wang, Qi-hao Guo and Jian-jun Wu

    Citation: Translational Neurodegeneration 2018 7:16

    Content type: Research

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  9. The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical studies. This study is to investigate the efficacy ...

    Authors: Zhenxin Zhang, Ming Shao, Shengdi Chen, Chunfeng Liu, Rong Peng, Yansheng Li, Jian Wang, Suiqiang Zhu, Qiumin Qu, Xiaoying Zhang, Haibo Chen, Xiangru Sun, Yanping Wang, Shenggang Sun, Baorong Zhang, Jimei Li…

    Citation: Translational Neurodegeneration 2018 7:14

    Content type: Research

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  10. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive...

    Authors: Qian-Qian Chen, Caroline Haikal, Wen Li, Ming-Tao Li, Zhan-You Wang and Jia-Yi Li

    Citation: Translational Neurodegeneration 2018 7:13

    Content type: Short report

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  11. The NIA-AA research framework proposes a biological definition of Alzheimer’s disease, where asymptomatic persons with amyloid deposition would be considered as having this disease prior to symptoms.

    Authors: S. Gauthier, H. Zhang, K. P. Ng, T.A. Pascoal and P. Rosa-Neto

    Citation: Translational Neurodegeneration 2018 7:12

    Content type: Review

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  12. Deep Brain Stimulation (DBS) therapy for the treatment of Parkinson’s Disease (PD) is now a well-established option for some patients. Postoperative standardized programming processes can improve the level of ...

    Authors: Shengdi Chen, Guodong Gao, Tao Feng and Jianguo Zhang

    Citation: Translational Neurodegeneration 2018 7:11

    Content type: Review

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  13. Brain consists of plenty of complicated cytoarchitecture. Gaussian-model based diffusion tensor imaging (DTI) is far from satisfactory interpretation of the structural complexity. Diffusion kurtosis imaging (D...

    Authors: Jia-Xing Cheng, Hong-Ying Zhang, Zheng-Kun Peng, Yao Xu, Hui Tang, Jing-Tao Wu and Jun Xu

    Citation: Translational Neurodegeneration 2018 7:10

    Content type: Research

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  14. Brain 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been utilized to monitor disease conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer’s dementia (AD). However, the conver...

    Authors: Hai Rong Ma, Li Qin Sheng, Ping Lei Pan, Gen Di Wang, Rong Luo, Hai Cun Shi, Zhen Yu Dai and Jian Guo Zhong

    Citation: Translational Neurodegeneration 2018 7:9

    Content type: Review

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  15. Parkinson’s disease (PD) is often accompanied by clinically identified depression. Providing effective pharmacotherapies that concomitantly treat both motor and psychological symptoms can pose a challenge to p...

    Authors: Alexandra M. Lesenskyj, Megan P. Samples, Jill M. Farmer and Christina R. Maxwell

    Citation: Translational Neurodegeneration 2018 7:8

    Content type: Review

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  16. Animal models of exercise and Parkinson’s disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic fac...

    Authors: Mark A. Hirsch, Erwin E. H. van Wegen, Mark A. Newman and Patricia C. Heyn

    Citation: Translational Neurodegeneration 2018 7:7

    Content type: Review

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  17. Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by patholo...

    Authors: Seyedeh Maryam Alavi Naini, Constantin Yanicostas, Rahma Hassan-Abdi, Sébastien Blondeel, Mohamed Bennis, Ryan J. Weiss, Yitzhak Tor, Jeffrey D. Esko and Nadia Soussi-Yanicostas

    Citation: Translational Neurodegeneration 2018 7:6

    Content type: Short report

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    The Correction to this article has been published in Translational Neurodegeneration 2020 9:45

  18. Nearly 30% of adults 40 years and older in the United States are on a statin. Their widespread use heightens the importance of careful consideration of their varied effects on the body. Although randomized con...

    Authors: Bob G. Schultz, Denise K. Patten and Daniel J. Berlau

    Citation: Translational Neurodegeneration 2018 7:5

    Content type: Review

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  19. Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly est...

    Authors: Belal Shohayeb, Mohamed Diab, Mazen Ahmed and Dominic Chi Hiung Ng

    Citation: Translational Neurodegeneration 2018 7:4

    Content type: Review

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  20. Hydrogen Sulfide (H2S) and Nitric Oxide (NO) have become recognized as important gaseous signaling molecules with enormous pharmacological effects, therapeutic value, and central physiological roles. NO is one of...

    Authors: Sandesh Panthi, Sumeet Manandhar and Kripa Gautam

    Citation: Translational Neurodegeneration 2018 7:3

    Content type: Review

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  21. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extr...

    Authors: Xiaoguang Du, Xinyi Wang and Meiyu Geng

    Citation: Translational Neurodegeneration 2018 7:2

    Content type: Review

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  23. Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confi...

    Authors: Ye Liu, Xiao-Ying Zhu, Xiao-Jin Zhang, Sheng-Han Kuo, William G. Ondo and Yun-Cheng Wu

    Citation: Translational Neurodegeneration 2017 6:35

    Content type: Research

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  24. In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s dise...

    Authors: Daniel Kam Yin Chan, Ying Hua Xu, Luke Kar Man Chan, Nady Braidy and George D. Mellick

    Citation: Translational Neurodegeneration 2017 6:33

    Content type: Review

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  25. PINK1 (PTEN-induced putative kinase 1) gene is the causal gene for recessive familial type 6 of Parkinson’s disease (PARK6), which is an early-onset autosomal recessive inherited neurodegenerative disease. PIN...

    Authors: Ji-feng Guo, Ling-yan Yao, Qi-ying Sun, Yi-ting Cui, Yang Yang, Qian Xu, Xin-xiang Yan and Bei-sha Tang

    Citation: Translational Neurodegeneration 2017 6:34

    Content type: Research

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  26. Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manif...

    Authors: Sebastian Aguiar, Bram van der Gaag and Francesco Albert Bosco Cortese

    Citation: Translational Neurodegeneration 2017 6:30

    Content type: Review

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  27. Tau vaccination and administration of anti-tau antibodies can prevent pathology and cognitive impairment in transgenic mouse models of tauopathy, suggesting that therapies which increase anti-tau antibodies mi...

    Authors: Andrea C. Klaver, Mary P. Coffey, David A. Bennett and David A. Loeffler

    Citation: Translational Neurodegeneration 2017 6:32

    Content type: Research

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  28. Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders....

    Authors: Rafael Lazo-Gomez and Ricardo Tapia

    Citation: Translational Neurodegeneration 2017 6:31

    Content type: Research

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  29. Extensive loss of donor neural stem cell (NSCs) due to ischemic stress and low rate of differentiation at the site of cell graft are two of the major issues that hamper optimal outcome in NSCs transplantation ...

    Authors: Parisa Tabeshmehr, Haider Kh Husnain, Mahin Salmannejad, Mahsa Sani, Seyed Mojtaba Hosseini and Mohammad Hossein Khorraminejad Shirazi

    Citation: Translational Neurodegeneration 2017 6:29

    Content type: Research

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  30. Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkins...

    Authors: Panchanan Maiti, Jayeeta Manna and Gary L. Dunbar

    Citation: Translational Neurodegeneration 2017 6:28

    Content type: Review

    Published on:

  31. The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping symptoms. It does not take into account the disease etiology or the highly var...

    Authors: Shirley Yin-Yu Pang, Kay-Cheong Teo, Jacob Shujui Hsu, Richard Shek-Kwan Chang, Miaoxin Li, Pak-Chung Sham and Shu-Leong Ho

    Citation: Translational Neurodegeneration 2017 6:27

    Content type: Review

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  33. Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestation...

    Authors: Yiwen Wu and Mark Hallett

    Citation: Translational Neurodegeneration 2017 6:26

    Content type: Review

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  35. Alzheimer’s disease (AD) is the most common age-dependent disease of dementia, and there is currently no cure available. This hallmark pathologies of AD are the presence of amyloid plaques and neurofibrillary ...

    Authors: Brati Das and Riqiang Yan

    Citation: Translational Neurodegeneration 2017 6:23

    Content type: Review

    Published on:

  38. Traumatic brain injury is among the most common causes of death and disability in youth and young adults. In addition to the acute risk of morbidity with moderate to severe injuries, traumatic brain injury is ...

    Authors: Marcela Cruz-Haces, Jonathan Tang, Glen Acosta, Joseph Fernandez and Riyi Shi

    Citation: Translational Neurodegeneration 2017 6:20

    Content type: Review

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  39. Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is associated with learning and memory impairment in the elderly. Recent studies have found that treating AD in the way of chromatin remod...

    Authors: Shuang-shuang Yang, Rui Zhang, Gang Wang and Yong-fang Zhang

    Citation: Translational Neurodegeneration 2017 6:19

    Content type: Review

    Published on:

  41. There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease (PD-MCI) and the coping strategies used by these caregivers.

    Authors: Ann J. Jones, Roeline G. Kuijer, Leslie Livingston, Daniel Myall, Kyla Horne, Michael MacAskill, Toni Pitcher, Paul T. Barrett, Tim J. Anderson and John C. Dalrymple-Alford

    Citation: Translational Neurodegeneration 2017 6:17

    Content type: Research

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  42. Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is...

    Authors: Wei Chen, Franziska Hopfner, Jos Steffen Becktepe and Günther Deuschl

    Citation: Translational Neurodegeneration 2017 6:16

    Content type: Review

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  44. Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for Parkinson’s disease (PD), the predictive effect of levodopa responsiveness on surgical outcomes was confirmed by some studies,...

    Authors: Xin-Ling Su, Xiao-Guang Luo, Hong Lv, Jun Wang, Yan Ren and Zhi-Yi He

    Citation: Translational Neurodegeneration 2017 6:14

    Content type: Research

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  45. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress (ER stress). HSP70 family, a chaperon like heat shock p...

    Authors: Hui Sun, Ming Jiang, Xing Fu, Qiong Cai, Jingxing Zhang, Yanxin Yin, Jia Guo, Lihua Yu, Yun Jiang, Yigang Liu, Liang Feng, Zhiyu Nie, Jianmin Fang and Lingjing Jin

    Citation: Translational Neurodegeneration 2017 6:12

    Content type: Research

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  46. Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on i...

    Authors: Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman and Peter Warnke

    Citation: Translational Neurodegeneration 2017 6:13

    Content type: Review

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  47. Recent studies have found that the functional catechol-O-methyltransferase (COMT) gene may be associated with the susceptibility to and pharmacotherapy of Parkinson’s disease (PD). In this case–control study, ...

    Authors: Yiwei Qian, Jiujiang Liu, Shaoqing Xu, Xiaodong Yang and Qin Xiao

    Citation: Translational Neurodegeneration 2017 6:11

    Content type: Research

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  48. Glutaminase 1 is a phosphate-activated metabolic enzyme that catalyzes the first step of glutaminolysis, which converts glutamine into glutamate. Glutamate is the major neurotransmitter of excitatory synapses,...

    Authors: Yuju Li, Justin Peer, Runze Zhao, Yinghua Xu, Beiqing Wu, Yi Wang, Changhai Tian, Yunlong Huang and Jialin Zheng

    Citation: Translational Neurodegeneration 2017 6:10

    Content type: Research

    Published on:

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