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  1. Content type: Review

    Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatme...

    Authors: Zhen Jiang, Wenzhang Wang, George Perry, Xiongwei Zhu and Xinglong Wang

    Citation: Translational Neurodegeneration 2015 4:14

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  2. Content type: Review

    Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease (PD) and other movement disorders symptoms along with some psychiatric conditions. Over ...

    Authors: Daniel Martinez-Ramirez, Wei Hu, Alberto R. Bona, Michael S. Okun and Aparna Wagle Shukla

    Citation: Translational Neurodegeneration 2015 4:12

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  3. Content type: Research

    Wnt/β-catenin signal has been reported to exert cytoprotective effects in cellular models of several diseases, including Parkinson’s disease (PD). This study aimed to investigate the neuroprotective effects of...

    Authors: Lei Wei, Li Ding, Ming-shu Mo, Ming Lei, Limin Zhang, Kang Chen and Pingyi Xu

    Citation: Translational Neurodegeneration 2015 4:11

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  4. Content type: Research

    In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in micro...

    Authors: Fan Zhang, Bo Su, Chunyu Wang, Sandra L. Siedlak, Siddhartha Mondragon-Rodriguez, Hyoung-gon Lee, Xinglong Wang, George Perry and Xiongwei Zhu

    Citation: Translational Neurodegeneration 2015 4:9

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  5. Content type: Review

    Alzheimer’s disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cogni...

    Authors: Siqiang Lai, Min Zhang, Dongsheng Xu, Yiying Zhang, Lisha Qiu, Changhai Tian and Jialin Charlie Zheng

    Citation: Translational Neurodegeneration 2015 4:7

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  6. Content type: Review

    α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein funct...

    Authors: Huda Saleh, Ayeh Saleh, Hailan Yao, Jie Cui, Yong Shen and Rena Li

    Citation: Translational Neurodegeneration 2015 4:5

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  7. Content type: Research

    Voxel-based morphometry (VBM) using structural brain MRI has been widely used for the assessment of impairment in Alzheimer’s disease (AD), but previous studies in VBM studies on AD remain inconsistent.

    Authors: Wen-Ying Wang, Jin-Tai Yu, Yong Liu, Rui-Hua Yin, Hui-Fu Wang, Jun Wang, Lin Tan, Joaquim Radua and Lan Tan

    Citation: Translational Neurodegeneration 2015 4:6

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  8. Content type: Review

    The approach to early Parkinson’s disease denotes the communication of the diagnosis and important decisions, such as when and how to start treatment. Evidence based medicine and guidelines indicate which drug...

    Authors: Fabrizio Stocchi, Laura Vacca and Fabiana G Radicati

    Citation: Translational Neurodegeneration 2015 4:4

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  9. Content type: Research

    Language impairment is relatively common in Parkinson’s disease (PD), but not all PD patients are susceptible to language problems. In this study, we identified among a sample of PD patients those pre-disposed...

    Authors: Lin Liu, Xiao-Guang Luo, Chui-Liang Dy, Yan Ren, Yu Feng, Hong-Mei Yu, Hong Shang and Zhi-Yi He

    Citation: Translational Neurodegeneration 2015 4:2

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  10. Content type: Research

    Nonmotor symptoms are common among patients with Parkinson’s disease (PD) and some may precede disease diagnosis.

    Authors: Honglei Chen, Edward J Zhao, Wen Zhang, Yi Lu, Rui Liu, Xuemei Huang, Anna J Ciesielski-Jones, Michele A Justice, Deborah S Cousins and Shyamal Peddada

    Citation: Translational Neurodegeneration 2015 4:1

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  11. Content type: Review

    A preferential dysfunction/loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) accounts for the main motor symptoms of Parkinson’s disease (PD), the most common degenerative movement di...

    Authors: Huaibin Cai, Guoxiang Liu, Lixin Sun and Jinhui Ding

    Citation: Translational Neurodegeneration 2014 3:27

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  12. Content type: Research

    Chronic levodopa (L-dopa) treatment in Parkinson’s disease (PD) is often associated with the development of motor complications, but the corresponding epidemiological data is rare in Chinese PD patients. The p...

    Authors: Wei Chen, Qin Xiao, Ming Shao, Tao Feng, Wei-Guo Liu, Xiao-Guang Luo, Xiao-Chun Chen, An-Mu Xie, Chun-Feng Liu, Zhen-Guo Liu, Yi-Ming Liu, Jian Wang and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2014 3:26

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  13. Content type: Research

    The transition metal copper enhances amyloid β aggregation and neurotoxicity, and in models of concomitant amyloid and tau pathology, copper also promotes tau aggregation. Since it is not clear if the effects ...

    Authors: Kellen Voss, Christopher Harris, Martina Ralle, Megan Duffy, Charles Murchison and Joseph F Quinn

    Citation: Translational Neurodegeneration 2014 3:24

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  14. Content type: Review

    Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple s...

    Authors: Kristi M Anderson, Katherine E Olson, Katherine A Estes, Ken Flanagan, Howard E Gendelman and R Lee Mosley

    Citation: Translational Neurodegeneration 2014 3:25

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  15. Content type: Review

    Mass spectrometry (MS)-based proteomics has developed into a battery of approaches that is exceedingly adept at identifying with high mass accuracy and precision any of the following: oxidative damage to prote...

    Authors: Ru-Jing Ren, Eric B Dammer, Gang Wang, Nicholas T Seyfried and Allan I Levey

    Citation: Translational Neurodegeneration 2014 3:23

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  16. Content type: Review

    Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with an exposed CMA-targeting motif to lysosomes for degradation and plays an important role in protein quality control and cellular h...

    Authors: Gang Wang and Zixu Mao

    Citation: Translational Neurodegeneration 2014 3:20

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  17. Content type: Review

    Mutant (MT) forms of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis—familial amyloidotic polyneuropathy (FAP). Until 20 years ago, FAP was thought to be an...

    Authors: Mitsuharu Ueda and Yukio Ando

    Citation: Translational Neurodegeneration 2014 3:19

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  18. Content type: Research

    A significant number of children diagnosed with autism spectrum disorder suffer a loss of previously-acquired skills, suggesting neurodegeneration or a type of progressive encephalopathy with an etiological ba...

    Authors: Brian S Hooker

    Citation: Translational Neurodegeneration 2014 3:16

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    The Retraction Note to this article has been published in Translational Neurodegeneration 2014 3:22

  19. Content type: Research

    Progressive cognitive decline is a feature of Huntington’s disease (HD), an inherited neurodegenerative movement disorder. Comprehensive neuropsychological testing is the ‘gold standard’ to establish cognitive...

    Authors: Eng A Toh, Michael R MacAskill, John C Dalrymple-Alford, Daniel J Myall, Leslie Livingston, Sandy AD Macleod and Tim J Anderson

    Citation: Translational Neurodegeneration 2014 3:15

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  20. Content type: Case report

    Hemiballism-hemichorea (HB-HC) is commonly used to describe the basal ganglion dysfunction in non-ketotic hyperglycemic elderly patients. Here we report two elderly female patients with acute onset of involunt...

    Authors: Yuyan Tan, Xiaoyu Xin, Qin Xiao, Shengdi Chen, Li Cao and Huidong Tang

    Citation: Translational Neurodegeneration 2014 3:14

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  21. Content type: Research

    Cardiovascular risk factors (CRF) were widely described as related to dementia. There are very few studies regarding this association in FTD. The objective of the study was to compare the frequency of CRF in o...

    Authors: Angel Golimstok, Nuria Cámpora, Juan I Rojas, María C Fernandez, Cristina Elizondo, Enrique Soriano and Edgardo Cristiano

    Citation: Translational Neurodegeneration 2014 3:13

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  22. Content type: Review

    Progress has been made in understanding the genetics and molecular biology of frontotemporal dementia (FTD). Targets for intervention have been identified, therapies are being developed, and clinical trials ar...

    Authors: Justin B Miller, Sarah J Banks, Gabriel C Léger and Jeffrey L Cummings

    Citation: Translational Neurodegeneration 2014 3:12

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  23. Content type: Research

    To evaluate the non-inferiority of pramipexole extended-release (ER) versus immediate-release (IR) in Chinese patients with Parkinson’s disease (PD) in a double-blind, randomized, parallel-group study.

    Authors: Ying Wang, Shenggang Sun, Suiqiang Zhu, Chunfeng Liu, Yiming Liu, Qing Di, Huifang Shang, Yan Ren, Changhong Lu, Mark Forrest Gordon, Nolwenn Juhel and Shengdi Chen

    Citation: Translational Neurodegeneration 2014 3:11

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  24. Content type: Review

    Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS) and retinal degeneration have been studied extensively and varying molecular mechanism...

    Authors: Shweta Modgil, Debomoy K Lahiri, Vijay L Sharma and Akshay Anand

    Citation: Translational Neurodegeneration 2014 3:9

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  25. Content type: Research

    Alzheimer’s disease (AD) is the most common form of dementia. At the present time, however, AD still lacks effective treatments. Our recent studies showed that chronic treatment with anesthetic propofol attenu...

    Authors: Yiying Zhang, Haijun Shao, Yuanlin Dong, Celeste A Swain, Buwei Yu, Weiming Xia and Zhongcong Xie

    Citation: Translational Neurodegeneration 2014 3:8

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  26. Content type: Review

    Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles (NFTs) is a common feature in a wide range of neurodegenerative diseases known as tauopathies, which include Alzheime...

    Authors: Eduardo Rigon Zimmer, Antoine Leuzy, Venkat Bhat, Serge Gauthier and Pedro Rosa-Neto

    Citation: Translational Neurodegeneration 2014 3:6

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  27. Content type: Review

    Cognitive impairments are highly prevalent in Parkinson’s disease (PD) and can substantially affect a patient’s quality of life. These impairments remain difficult to manage with current clinical therapies, bu...

    Authors: Danielle K Murray, Matthew A Sacheli, Janice J Eng and A Jon Stoessl

    Citation: Translational Neurodegeneration 2014 3:5

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  28. Content type: Review

    Adult-onset autosomal dominant leukodystrophy (ADLD) is a progressive and fatal hereditary demyelination disorder characterized initially by autonomic dysfunction and loss of myelin in the central nervous syst...

    Authors: Shu-Ting Lin, Mary Y Heng, Louis J Ptáček and Ying-Hui Fu

    Citation: Translational Neurodegeneration 2014 3:4

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  29. Content type: Review

    Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory movement disorders, and has been approved by the United States Food and Drug Administration for treatment of dystonia. ...

    Authors: Wei Hu and Matt Stead

    Citation: Translational Neurodegeneration 2014 3:2

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  30. Content type: Research

    Autism spectrum disorder (ASD) is defined by standardized criteria of qualitative impairments in social interaction, qualitative impairments in communication, and restricted and stereotyped patterns of behavio...

    Authors: David A Geier, Brian S Hooker, Janet K Kern, Paul G King, Lisa K Sykes and Mark R Geier

    Citation: Translational Neurodegeneration 2013 2:25

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  31. Content type: Research

    Alzheimer’s disease (AD), the most common dementia, is characterized by potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as amyloid plaques and neurofibrillary tangles (NF...

    Authors: Shuk Wai Ho, Yuk Tung Chanel Tsui, Ting Ting Wong, Stanley Kwok-Kuen Cheung, William B Goggins, Lau Ming Yi, Kwok Kin Cheng and Larry Baum

    Citation: Translational Neurodegeneration 2013 2:24

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  32. Content type: Research

    Parkinson’s disease characterized by oxidative stress and mitochondrial damage in the pars compacta of substantia nigra remains a challenge to manage with an added disadvantage of side effects of L-levo dopa, ...

    Authors: Uvarajan Sampath and Vanisree Arambakkam Janardhanam

    Citation: Translational Neurodegeneration 2013 2:23

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  33. Content type: Review

    For the last 50 years, levodopa has been the cornerstone of Parkinson’s disease management. However, a majority of patients develop motor complications a few years after therapy onset. Deep brain stimulation h...

    Authors: Raja Mehanna and Eugene C Lai

    Citation: Translational Neurodegeneration 2013 2:22

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  34. Content type: Short report

    The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up...

    Authors: Nady Braidy, Wei-Ping Gai, Ying Hua Xu, Perminder Sachdev, Gilles J Guillemin, Xing-Mai Jiang, J William O Ballard, Martin P Horan, Zhi Ming Fang, Beng H Chong and DanielKam Yin Chan

    Citation: Translational Neurodegeneration 2013 2:20

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  35. Content type: Review

    This review is to analyze the role of National Natural Science Foundation of China (NSFC) on the development of basic research of Parkinson’s disease from 1990 to 2012. Data on the total number of projects and...

    Authors: Heqi Cao, Gang Chen and Erdan Dong

    Citation: Translational Neurodegeneration 2013 2:18

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  36. Content type: Review

    Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and abilities. Lo...

    Authors: Janet K Kern, David A Geier, Lisa K Sykes and Mark R Geier

    Citation: Translational Neurodegeneration 2013 2:17

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