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  2. Content type: Review

    Parkinson’s disease (PD) is referring to the multi-systemic α-synucleinopathy with Lewy bodies deposited in midbrain. In ageing, the environmental and genetic factors work together and overactive major histoco...

    Authors: Li Chen, Mingshu Mo, Guangning Li, Luan Cen, Lei Wei, Yousheng Xiao, Xiang Chen, Shaomin Li, Xinling Yang, Shaogang Qu and Pingyi Xu

    Citation: Translational Neurodegeneration 2016 5:16

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  3. Content type: Research

    Dopamine transporter based imaging has high diagnostic performance in distinguishing patients with Parkinson’s disease (PD) from patients with non-Parkinsonian syndromes. Our previous study indicated that the ...

    Authors: Wenyan Kang, Fangyi Dong, Dunhui Li, Thomas J. Quinn, Shengdi Chen and Jun Liu

    Citation: Translational Neurodegeneration 2016 5:15

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  4. Content type: Review

    Parkinson’s disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic (DA) neurons in the substantia nigra pars compacta and the formation of Lewy bodies ...

    Authors: Qingsong Hu and Guanghui Wang

    Citation: Translational Neurodegeneration 2016 5:14

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  6. Content type: Review

    Parkinson’s disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia an...

    Authors: Shengdi Chen, Piu Chan, Shenggang Sun, Haibo Chen, Baorong Zhang, Weidong Le, Chunfeng Liu, Guoguang Peng, Beisha Tang, Lijuan Wang, Yan Cheng, Ming Shao, Zhenguo Liu, Zhenfu Wang, Xiaochun Chen, Mingwei Wang…

    Citation: Translational Neurodegeneration 2016 5:12

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  7. Content type: Review

    Parkinson’s disease (PD) is a common heterogeneous neurodegenerative disorder in elder population. Parkinson’s disease dementia (PDD) is one of the most common non-motor manifestations in PD patients. No compr...

    Authors: Yaqian Xu, Jing Yang and Huifang Shang

    Citation: Translational Neurodegeneration 2016 5:11

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  8. Content type: Review

    Benign tremulous parkinsonism (BTP) is characterized by a prominent tremor that occurs both at rest and with action in conjunction with other mild features of parkinsonism. The progression of symptoms is typic...

    Authors: Wissam Deeb, Wei Hu, Leonardo Almeida, Addie Patterson, Daniel Martinez-Ramirez and Aparna Wagle Shukla

    Citation: Translational Neurodegeneration 2016 5:10

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  9. Content type: Research

    Fatigue, which is commonly observed in Parkinson’s disease (PD), can greatly reduce quality of life and is difficult to treat. We here aimed to investigate the prevalence and characteristics of fatigue among P...

    Authors: Rao Fu, Xiao-Guang Luo, Yan Ren, Zhi-Yi He and Hong Lv

    Citation: Translational Neurodegeneration 2016 5:9

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  10. Content type: Research

    China has more cases of Alzheimer’s disease (AD) than any other country in the world. As training to recognize and manage dementia is in its early stage, it is important to study clinicians’ current prescripti...

    Authors: Chun-Xia Ban, Shi-Fu Xiao, Xiang Lin, Tao Wang, Qi Qiu, Min-Jie Zhu and Xia Li

    Citation: Translational Neurodegeneration 2016 5:8

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  12. Content type: Research

    DJ-1 has been thought as a candidate biomarker for Parkinson’s disease (PD). It was found reduced in PD brains, CSF and saliva, although there were conflicting results. How DJ-1 expression may be regulated is ...

    Authors: Yuyan Tan, Li Wu, Dunhui Li, Xiaoli Liu, Jianqing Ding and Shengdi Chen

    Citation: Translational Neurodegeneration 2016 5:5

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  13. Content type: Research

    MicroRNAs (miRNAs) are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression. Measurements of miRNAs in cerebrospinal fluid (CSF) and blood have just started gaining...

    Authors: Sofie Sølvsten Sørensen, Ann-Britt Nygaard and Thomas Christensen

    Citation: Translational Neurodegeneration 2016 5:6

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  14. Content type: Research

    Levodopa and dopamine agonists are the main treatments for Parkinson’s disease (PD) in recent years. Increased drug dosages are linked to some severe side effects, one of which is impulse control disorders (IC...

    Authors: Xue-Ping Wang, Ming Wei and Qin Xiao

    Citation: Translational Neurodegeneration 2016 5:4

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  16. Content type: Review

    Brain-derived neurotrophic factor (BDNF) regulates a variety of biological processes predominantly via binding to the transmembrane receptor tyrosine kinase TrkB. It is a potential therapeutic target in numero...

    Authors: Chaoyang Liu, Chi Bun Chan and Keqiang Ye

    Citation: Translational Neurodegeneration 2016 5:2

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  18. Content type: Short report

    Freezing of gait (FoG) is a common and debilitating condition in Parkinson’s disease (PD) associated with executive dysfunction. A subtype of FoG does not respond to dopaminergic therapy and may be related to ...

    Authors: Gonzalo J. Revuelta, Aaron Embry, Jordan J. Elm, Chris Gregory, Amy Delambo, Steve Kautz and Vanessa K. Hinson

    Citation: Translational Neurodegeneration 2015 4:24

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  19. Content type: Research

    α–synuclein (α–syn) is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease (PD) and certain other neurodegenerative disorders. Recent studies have exp...

    Authors: Namratha Sastry, Wang Zheng, Guoxiang Liu, Helen Wang, Xi Chen, Michael Cai, Parth Contractor, Carmelo Sgobio, Lixin Sun, Chengsong Xie and Huaibin Cai

    Citation: Translational Neurodegeneration 2015 4:23

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  20. Content type: Review

    Common neurodegenerative diseases include Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). Transcranial magnetic stimulation (TMS) is a non...

    Authors: Zhen Ni and Robert Chen

    Citation: Translational Neurodegeneration 2015 4:22

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  26. Content type: Review

    Parkinson’s disease (PD) is one of the most common neurodegenerative disorders of aging, characterized by the degeneration of dopamine neurons (DA neurons) in the substantial nigra, leading to the advent of bo...

    Authors: Fabin Han, Deborah Baremberg, Junyu Gao, Jing Duan, Xianjie Lu, Nan Zhang and Qingfa Chen

    Citation: Translational Neurodegeneration 2015 4:16

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  27. Content type: Research

    Healthcare resource utilisation for Alzheimer’s disease (AD) in China is not well understood. This Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in u...

    Authors: Xin Yu, Shengdi Chen, Xiaochun Chen, Jianjun Jia, Chunhou Li, Cong Liu, Mondher Toumi and Dominique Milea

    Citation: Translational Neurodegeneration 2015 4:15

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  28. Content type: Review

    Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of motor neurons in the brainstem and spinal cord. Currently, there is no cure or effective treatme...

    Authors: Zhen Jiang, Wenzhang Wang, George Perry, Xiongwei Zhu and Xinglong Wang

    Citation: Translational Neurodegeneration 2015 4:14

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  30. Content type: Review

    Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease (PD) and other movement disorders symptoms along with some psychiatric conditions. Over ...

    Authors: Daniel Martinez-Ramirez, Wei Hu, Alberto R. Bona, Michael S. Okun and Aparna Wagle Shukla

    Citation: Translational Neurodegeneration 2015 4:12

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  31. Content type: Research

    Wnt/β-catenin signal has been reported to exert cytoprotective effects in cellular models of several diseases, including Parkinson’s disease (PD). This study aimed to investigate the neuroprotective effects of...

    Authors: Lei Wei, Li Ding, Ming-shu Mo, Ming Lei, Limin Zhang, Kang Chen and Pingyi Xu

    Citation: Translational Neurodegeneration 2015 4:11

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  33. Content type: Research

    In Alzheimer disease (AD), hyperphosphorylation of tau proteins results in microtubule destabilization and cytoskeletal abnormalities. Our prior ultra-morphometric studies documented a clear reduction in micro...

    Authors: Fan Zhang, Bo Su, Chunyu Wang, Sandra L. Siedlak, Siddhartha Mondragon-Rodriguez, Hyoung-gon Lee, Xinglong Wang, George Perry and Xiongwei Zhu

    Citation: Translational Neurodegeneration 2015 4:9

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  35. Content type: Review

    Alzheimer’s disease (AD) is a prominent form of dementia, characterized by aggregation of the amyloid β-peptide (Aβ) plaques and neurofibrillary tangles, loss of synapses and neurons, and degeneration of cogni...

    Authors: Siqiang Lai, Min Zhang, Dongsheng Xu, Yiying Zhang, Lisha Qiu, Changhai Tian and Jialin Charlie Zheng

    Citation: Translational Neurodegeneration 2015 4:7

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  36. Content type: Review

    α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein funct...

    Authors: Huda Saleh, Ayeh Saleh, Hailan Yao, Jie Cui, Yong Shen and Rena Li

    Citation: Translational Neurodegeneration 2015 4:5

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  37. Content type: Research

    Voxel-based morphometry (VBM) using structural brain MRI has been widely used for the assessment of impairment in Alzheimer’s disease (AD), but previous studies in VBM studies on AD remain inconsistent.

    Authors: Wen-Ying Wang, Jin-Tai Yu, Yong Liu, Rui-Hua Yin, Hui-Fu Wang, Jun Wang, Lin Tan, Joaquim Radua and Lan Tan

    Citation: Translational Neurodegeneration 2015 4:6

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  38. Content type: Review

    The approach to early Parkinson’s disease denotes the communication of the diagnosis and important decisions, such as when and how to start treatment. Evidence based medicine and guidelines indicate which drug...

    Authors: Fabrizio Stocchi, Laura Vacca and Fabiana G Radicati

    Citation: Translational Neurodegeneration 2015 4:4

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  40. Content type: Research

    Language impairment is relatively common in Parkinson’s disease (PD), but not all PD patients are susceptible to language problems. In this study, we identified among a sample of PD patients those pre-disposed...

    Authors: Lin Liu, Xiao-Guang Luo, Chui-Liang Dy, Yan Ren, Yu Feng, Hong-Mei Yu, Hong Shang and Zhi-Yi He

    Citation: Translational Neurodegeneration 2015 4:2

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  41. Content type: Research

    Nonmotor symptoms are common among patients with Parkinson’s disease (PD) and some may precede disease diagnosis.

    Authors: Honglei Chen, Edward J Zhao, Wen Zhang, Yi Lu, Rui Liu, Xuemei Huang, Anna J Ciesielski-Jones, Michele A Justice, Deborah S Cousins and Shyamal Peddada

    Citation: Translational Neurodegeneration 2015 4:1

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  42. Content type: Review

    A preferential dysfunction/loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) accounts for the main motor symptoms of Parkinson’s disease (PD), the most common degenerative movement di...

    Authors: Huaibin Cai, Guoxiang Liu, Lixin Sun and Jinhui Ding

    Citation: Translational Neurodegeneration 2014 3:27

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  43. Content type: Research

    Chronic levodopa (L-dopa) treatment in Parkinson’s disease (PD) is often associated with the development of motor complications, but the corresponding epidemiological data is rare in Chinese PD patients. The p...

    Authors: Wei Chen, Qin Xiao, Ming Shao, Tao Feng, Wei-Guo Liu, Xiao-Guang Luo, Xiao-Chun Chen, An-Mu Xie, Chun-Feng Liu, Zhen-Guo Liu, Yi-Ming Liu, Jian Wang and Sheng-Di Chen

    Citation: Translational Neurodegeneration 2014 3:26

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  44. Content type: Research

    The transition metal copper enhances amyloid β aggregation and neurotoxicity, and in models of concomitant amyloid and tau pathology, copper also promotes tau aggregation. Since it is not clear if the effects ...

    Authors: Kellen Voss, Christopher Harris, Martina Ralle, Megan Duffy, Charles Murchison and Joseph F Quinn

    Citation: Translational Neurodegeneration 2014 3:24

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  45. Content type: Review

    Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include, but are not limited to, multiple s...

    Authors: Kristi M Anderson, Katherine E Olson, Katherine A Estes, Ken Flanagan, Howard E Gendelman and R Lee Mosley

    Citation: Translational Neurodegeneration 2014 3:25

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  46. Content type: Review

    Mass spectrometry (MS)-based proteomics has developed into a battery of approaches that is exceedingly adept at identifying with high mass accuracy and precision any of the following: oxidative damage to prote...

    Authors: Ru-Jing Ren, Eric B Dammer, Gang Wang, Nicholas T Seyfried and Allan I Levey

    Citation: Translational Neurodegeneration 2014 3:23

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  49. Content type: Review

    Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with an exposed CMA-targeting motif to lysosomes for degradation and plays an important role in protein quality control and cellular h...

    Authors: Gang Wang and Zixu Mao

    Citation: Translational Neurodegeneration 2014 3:20

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  50. Content type: Review

    Mutant (MT) forms of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis—familial amyloidotic polyneuropathy (FAP). Until 20 years ago, FAP was thought to be an...

    Authors: Mitsuharu Ueda and Yukio Ando

    Citation: Translational Neurodegeneration 2014 3:19

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Translational Neurodegeneration

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