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  1. Parkinson’s disease (PD) is characterized by intra-neuronal deposition of the protein α-synuclein (α-syn) and by deficiencies of the catecholamines dopamine and norepinephrine (NE) in the brain and heart. Accu...

    Authors: Risa Isonaka, Patti Sullivan and David S. Goldstein
    Citation: Translational Neurodegeneration 2022 11:15
  2. Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degene...

    Authors: Yi-Qing Lv, Lin Yuan, Yan Sun, Hao-Wen Dou, Ji-Hui Su, Zhi-Pan Hou, Jia-Yi Li and Wen Li
    Citation: Translational Neurodegeneration 2022 11:14
  3. Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B (encoding a copper-transporting P-type ATPase) variants that shows various characteristics according to race and geogr...

    Authors: Shijie Zhang, Wenming Yang, Xiang Li, Pei Pei, Ting Dong, Yue Yang and Jing Zhang
    Citation: Translational Neurodegeneration 2022 11:13
  4. The ultimate goal in Parkinson's disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-...

    Authors: Philipp Mahlknecht, Kathrin Marini, Mario Werkmann, Werner Poewe and Klaus Seppi
    Citation: Translational Neurodegeneration 2022 11:11
  5. Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are one of the most frequent genetic causes of both familial and sporadic Parkinson’s disease (PD). Mounting evidence has demonstrated pathological simil...

    Authors: Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2022 11:10
  6. Accumulating α-synuclein (α-syn) aggregates in neurons and glial cells are the staples of many synucleinopathy disorders, such as Parkinson’s disease (PD). Since brain adenosine becomes greatly elevated in age...

    Authors: Elisabet Jakova, Mohamed Taha Moutaoufik, Jeremy S. Lee, Mohan Babu and Francisco S. Cayabyab
    Citation: Translational Neurodegeneration 2022 11:9
  7. Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (AD), a similar association in humans is yet to be established. The first aim...

    Authors: Hannes Devos, Kathleen Gustafson, Ke Liao, Pedram Ahmadnezhad, Bradley Estes, Laura E. Martin, Jonathan D. Mahnken, William M. Brooks and Jeffrey M. Burns
    Citation: Translational Neurodegeneration 2022 11:8
  8. Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of ...

    Authors: Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang and Gabor G. Kovacs
    Citation: Translational Neurodegeneration 2022 11:7
  9. Tai Chi has been shown to improve motor symptoms in Parkinson’s disease (PD), but its long-term effects and the related mechanisms remain to be elucidated. In this study, we investigated the effects of long-te...

    Authors: Gen Li, Pei Huang, Shi-Shuang Cui, Yu-Yan Tan, Ya-Chao He, Xin Shen, Qin-Ying Jiang, Ping Huang, Gui-Ying He, Bin-Yin Li, Yu-Xin Li, Jin Xu, Zheng Wang and Sheng-Di Chen
    Citation: Translational Neurodegeneration 2022 11:6
  10. Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent two most common genetic causes of Parkinson’s disease (PD). Both genes are important in the autophagic-lysosomal pathway (A...

    Authors: Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung, David Boyer Ramsden and Shu-Leong Ho
    Citation: Translational Neurodegeneration 2022 11:5
  11. The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzhe...

    Authors: Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev and Michael R. Kreutz
    Citation: Translational Neurodegeneration 2022 11:2
  12. Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may he...

    Authors: Nuole Zhu, Miguel Santos-Santos, Ignacio Illán-Gala, Victor Montal, Teresa Estellés, Isabel Barroeta, Miren Altuna, Javier Arranz, Laia Muñoz, Olivia Belbin, Isabel Sala, Maria Belén Sánchez-Saudinós, Andrea Subirana, Laura Videla, Jordi Pegueroles, Rafael Blesa…
    Citation: Translational Neurodegeneration 2021 10:50

    The Correction to this article has been published in Translational Neurodegeneration 2023 12:21

  13. Alzheimer’s disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline. Failures in the development of therapeutics targeting amyloid-β (Aβ...

    Authors: Hyeon soo Kim, Sujin Kim, Soo Jung Shin, Yong Ho Park, Yunkwon Nam, Chae won Kim, Kang won Lee, Sung-Min Kim, In Duk Jung, Hyun Duk Yang, Yeong-Min Park and Minho Moon
    Citation: Translational Neurodegeneration 2021 10:49
  14. Alzheimer’s disease (AD) is the most common cause of dementia, and is characterized by amyloid-β (Aβ) plaques and tauopathy. Reducing Aβ has been considered a major AD treatment strategy in pharmacological and...

    Authors: Mincheol Park, Gia Minh Hoang, Thien Nguyen, Eunkyung Lee, Hyun Jin Jung, Youngshik Choe, Moon Hwan Lee, Jae Youn Hwang, Jae Gwan Kim and Tae Kim
    Citation: Translational Neurodegeneration 2021 10:48
  15. Parkinson’s disease (PD) is an incurable, devastating disorder that is characterized by pathological protein aggregation and neurodegeneration in the substantia nigra. In recent years, growing evidence has imp...

    Authors: Anastazja M. Gorecki, Chidozie C. Anyaegbu and Ryan S. Anderton
    Citation: Translational Neurodegeneration 2021 10:47
  16. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axonal proje...

    Authors: Frances Theunissen, Phillip K. West, Samuel Brennan, Bojan Petrović, Kosar Hooshmand, P. Anthony Akkari, Matt Keon and Boris Guennewig
    Citation: Translational Neurodegeneration 2021 10:46
  17. Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dy...

    Authors: Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen and Dan Liu
    Citation: Translational Neurodegeneration 2021 10:45
  18. Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies, but this is rarely reported in...

    Authors: So Hee Park, Kyoungwon Baik, Seun Jeon, Won Seok Chang, Byoung Seok Ye and Jin Woo Chang
    Citation: Translational Neurodegeneration 2021 10:44
  19. The dopaminergic nigrostriatal neurons (DA cells) in healthy people present a slow degeneration with aging, which produces cellular debris throughout life. About 2%–5% of people present rapid cell degeneration...

    Authors: Ingrid Morales, Ricardo Puertas-Avendaño, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate and Manuel Rodriguez
    Citation: Translational Neurodegeneration 2021 10:43
  20. Although many causative genes have been uncovered in recent years, genetic diagnosis is still missing for approximately 50% of autosomal recessive cerebellar ataxia (ARCA) patients. Few studies have been perfo...

    Authors: Hao-Ling Cheng, Ya-Ru Shao, Yi Dong, Hai-Lin Dong, Lu Yang, Yin Ma, Ying Shen and Zhi-Ying Wu
    Citation: Translational Neurodegeneration 2021 10:40
  21. Parkinson’s disease (PD) is a common neurodegenerative disorder that primarily affects the elderly. While the etiology of PD is likely multifactorial with the involvement of genetic, environmental, aging and o...

    Authors: Changjing Wang, Tongtong Yang, Meiyu Liang, Junxia Xie and Ning Song
    Citation: Translational Neurodegeneration 2021 10:39
  22. Amyloid-β (Aβ) immunotherapy is a promising therapeutic strategy in the fight against Alzheimer’s disease (AD). A number of monoclonal antibodies have entered clinical trials for AD. Some of them have failed d...

    Authors: Fadi Rofo, Jos Buijs, Ronny Falk, Ken Honek, Lars Lannfelt, Anna M. Lilja, Nicole G. Metzendorf, Tobias Gustavsson, Dag Sehlin, Linda Söderberg and Greta Hultqvist
    Citation: Translational Neurodegeneration 2021 10:38
  23. New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promisi...

    Authors: Neus Barranco, Virginia Plá, Daniel Alcolea, Irene Sánchez-Domínguez, Reiner Fischer-Colbrie, Isidro Ferrer, Alberto Lleó and Fernando Aguado
    Citation: Translational Neurodegeneration 2021 10:37
  24. Alzheimer’s disease (AD) is the most common cause of dementia, affecting approximately 40 million people worldwide. The ineffectiveness of the available pharmacological treatments against AD has fostered resea...

    Authors: Francisca Monteiro, Ioannis Sotiropoulos, Óscar Carvalho, Nuno Sousa and Filipe S. Silva
    Citation: Translational Neurodegeneration 2021 10:36
  25. There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which structural networks are...

    Authors: Wenbin Li, Qianqian Wei, Yanbing Hou, Du Lei, Yuan Ai, Kun Qin, Jing Yang, Graham J. Kemp, Huifang Shang and Qiyong Gong
    Citation: Translational Neurodegeneration 2021 10:35
  26. β Amyloid (Aβ)-mediated neuronal hyperactivity, a key feature of the early stage of Alzheimer’s disease (AD), is recently proposed to be initiated by the suppression of glutamate reuptake. Nevertheless, the un...

    Authors: Yifei Bao, Xin Yang, Yi Fu, Zhengyan Li, Ru Gong and Wei Lu
    Citation: Translational Neurodegeneration 2021 10:34
  27. Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging. Corr...

    Authors: Heather M. Wilkins and Russell H. Swerdlow
    Citation: Translational Neurodegeneration 2021 10:33
  28. The combinatorial effect of multiple genetic factors calculated as a polygenic risk score (PRS) has been studied to predict disease progression to Alzheimer’s disease (AD) from mild cognitive impairment (MCI)....

    Authors: Jung-Min Pyun, Young Ho Park, Keon-Joo Lee, SangYun Kim, Andrew J. Saykin and Kwangsik Nho
    Citation: Translational Neurodegeneration 2021 10:32
  29. Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light chains (NfL) could ...

    Authors: Simon Witzel, Felix Frauhammer, Petra Steinacker, David Devos, Pierre-François Pradat, Vincent Meininger, Steffen Halbgebauer, Patrick Oeckl, Joachim Schuster, Simon Anders, Johannes Dorst, Markus Otto and Albert C. Ludolph
    Citation: Translational Neurodegeneration 2021 10:31
  30. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons, leading to paralysis and eventually death. Symptomatic treatments such as inhibition...

    Authors: Xiaojiao Xu, Dingding Shen, Yining Gao, Qinming Zhou, You Ni, Huanyu Meng, Hongqin Shi, Weidong Le, Shengdi Chen and Sheng Chen
    Citation: Translational Neurodegeneration 2021 10:29
  31. The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with the revised El Escori...

    Authors: Dongchao Shen, Xunzhe Yang, Yanying Wang, Di He, Xiaohan Sun, Zhengyi Cai, Jinyue Li, Mingsheng Liu and Liying Cui
    Citation: Translational Neurodegeneration 2021 10:28
  32. Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to m...

    Authors: Feng-Chen Bi, Xin-He Yang, Xiao-Yu Cheng, Wen-Bin Deng, Xiao-Li Guo, Hui Yang, Yin Wang, Juan Li and Yao Yao
    Citation: Translational Neurodegeneration 2021 10:27
  33. Blood-based test for predicting disease progression and early diagnosis of Parkinson’s disease (PD) is an unmet need in the clinic. The profiles of microRNAs (miRNAs) are regarded as potential diagnostic bioma...

    Authors: Shulei He, Lu Huang, Ci Shao, Tiejian Nie, Li Xia, Bozhou Cui, Fangfang Lu, Lin Zhu, Bolin Chen and Qian Yang
    Citation: Translational Neurodegeneration 2021 10:25
  34. Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impair...

    Authors: Ilaria Pagnoni, Elena Gobbi, Enrico Premi, Barbara Borroni, Giuliano Binetti, Maria Cotelli and Rosa Manenti
    Citation: Translational Neurodegeneration 2021 10:24
  35. Gait problems are an important symptom in Parkinson’s disease (PD), a progressive neurodegenerative disease. Transcranial direct current stimulation (tDCS) is a neuromodulatory intervention that can modulate c...

    Authors: Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei and Michael A. Nitsche
    Citation: Translational Neurodegeneration 2021 10:22
  36. Accumulation of alpha-synuclein (α-syn) is a main pathological hallmark of Parkinson’s and related diseases, which are collectively known as synucleinopathies. Growing evidence has supported that the same prot...

    Authors: Di Liu, Jian-Jun Guo, Ji-Hui Su, Alexander Svanbergsson, Lin Yuan, Caroline Haikal, Wen Li, Gunnar Gouras and Jia-Yi Li
    Citation: Translational Neurodegeneration 2021 10:20
  37. Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PAR...

    Authors: Kai Yu Ma, Michiel R. Fokkens, Fulvio Reggiori, Muriel Mari and Dineke S. Verbeek
    Citation: Translational Neurodegeneration 2021 10:19
  38. The aggregation of amyloid β (Aβ) is central in the pathogenesis of Alzheimer’s disease (AD). Recently it has been shown that specifically, larger, Thioflavin T-binding Aβ aggregates are associated with increa...

    Authors: Mari Aksnes, Hans Christian D. Aass, Ann Tiiman, Trine Holt Edwin, Lars Terenius, Nenad Bogdanović, Vladana Vukojević and Anne-Brita Knapskog
    Citation: Translational Neurodegeneration 2021 10:18
  39. Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS...

    Authors: David Bayer, Stefano Antonucci, Hans-Peter Müller, Rami Saad, Luc Dupuis, Volker Rasche, Tobias M. Böckers, Albert C. Ludolph, Jan Kassubek and Francesco Roselli
    Citation: Translational Neurodegeneration 2021 10:17
  40. Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions (introns) and ligates coding regions (exons) into a continuous mes...

    Authors: Dunhui Li, Craig Stewart McIntosh, Frank Louis Mastaglia, Steve Donald Wilton and May Thandar Aung-Htut
    Citation: Translational Neurodegeneration 2021 10:16

    The Correction to this article has been published in Translational Neurodegeneration 2021 10:41

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