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Table 2 Correlation of cortical thickness signature with clinical parameters in derivation samples of age-matched DLB and healthy controls

From: Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study

 

DLB-pattern

AD-pattern

Mean cortical thickness

Correlation coefficient

P value

Correlation coefficient

P value

Correlation coefficient

P value

MMSE

− 0.31

0.035

− 0.088

0.55

0.37

0.011

Cognition (MDS-UPDRS part I)

0.051

0.79

0.17

0.41

− 0.64

4.18 × 10–4

MDS-UPDRS part I 

− 0.042

0.92

0.12

0.52

− 0.45

0.017

MDS-UPDRS part II 

0.041

0.90

− 0.16

0.42

− 0.52

0.0045

MDS-UPDRS part III 

0.051

0.87

0.24

0.26

− 0.58

0.0029

Digit span test

− 0.11

0.58

0.22

0.28

0.053

0.80

TMT-A

− 0.55

0.024

− 0.081

0.79

0.058

0.84

CWST

− 0.24

0.32

− 0.26

0.35

− 0.11

0.69

BNT

− 0.35

0.062

− 0.095

0.65

0.48

0.013

RCFT

− 0.54

0.0047

− 0.19

0.38

0.33

0.12

SVLTi

− 0.11

0.56

− 0.065

0.75

0.37

0.060

SVLTd

− 0.25

0.18

− 0.089

0.66

0.32

0.10

SVLTr

− 0.16

0.41

0.14

0.49

0.50

0.0078

COWAT

0.083

0.73

0.38

0.16

− 0.028

0.92

TMT-B

− 0.56

0.036

− 0.29

0.33

0.24

0.41

  1. Age and sex were included as cofactors for correlation analysis between cortical thickness pattern score and clinical variables MDS-UPDRS part I (except for cognition subscore), II and III. Age, sex and education year were included as cofactors in the correlation analysis between cortical thickness patterns and cognitive profiles (Cognition subscore from MDS-UPDRS part I and scores from neuropsychological tests)
  2. The significant values (P < 0.05) are shown in bold
  3. BNT Boston Naming Test, COWAT Controlled Oral Word Association Test, CWST Korean Color Word Stroop Test, DLB Dementia with Lewy bodies, MDS-UPDRS Movement Disorders Society-Unified Parkinson Disease Rating Scale, RCFT Rey Complex Figure Test copy, SVLT Seoul Verbal Learning Test, TMT Trail Making Test
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