Fig. 3

Longitudinal analyses of cortical thickness signature over 4 years of follow-up in iRBD. a Longitudinal change of individual DLB-pattern scores in dementia-first converters. Patients with the pre-conversion state are marked with a light blue color and patients after conversion are marked with dark blue. The time of phenoconversion was marked with a vertical dotted line. The best cut-off discriminating future dementia-first and parkinsonism-first converters is  marked as a horizontal dotted line (1 standard deviation from healthy control, AUC = 0.938). b Longitudinal change of individual DLB-pattern scores in parkinsonism-first converters as the same format in a. c, d Progression of DLB-pattern scores from prodromal stage to the converted stage in dementia-first converters (c) and parkinsonism-first converters (d). The shading represents 95% confidence. The vertical dotted line represents the timing of conversion. The horizontal dotted line is from the cut-off value in a. e, f Longitudinal change of mean cortical thickness from the baseline to 2-year and 4-year follow-ups in non-converters (e) and converters (f). g Comparison of the delta value (change of mean cortical thickness over 4 years) between non-converters and converters in iRBD patients (rank-sum test, *P < 0.05)