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Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study

Fig. 2

Topography of cortical thickness signature and its expression in different groups including converters/non-converters in iRBD. a Spatial map representing the DLB-pattern derived from DLB patients and healthy controls. Red and blue colors represent positive and negative contributions to the DLB-pattern, respectively. b Group comparison of DLB-pattern scores across different groups. The DLB-pattern scores were normalized with the mean and standard deviation of healthy controls. The thick horizontal lines and error bars represent the mean and standard error mean (sem), respectively. The P values were calculated with Kruskal–Wallis test with Dunn’s post-hoc test (*P < 0.05, *** P < 0.001). c Distribution of the baseline DLB-pattern scores of future converters (orange) and non-converters (gray) in total iRBD patients. Rank-sum test, N.S: not significant. d Distribution of the baseline DLB-pattern scores in future dementia-first converters (blue) and parkinsonism-first converters (red) in the iRBD cohort. (rank-sum test, **P < 0.01). e Spatial map representing the AD-related cortical thickness covariance pattern (AD-pattern) derived from AD patients and healthy controls. Red and blue colors represent positive and negative contributions to the AD-pattern pattern, respectively. f Group comparison of the AD-pattern scores across different groups. The error bar represents the mean and standard error mean (sem), respectively. The P values were calculated with Kruskal–Wallis test with Dunn’s post-hoc test. (*P < 0.05, ** P < 0.01, *** P < 0.001). g Distribution of the baseline AD-pattern scores of future converters (orange) and non-converters (gray) in total iRBD patients. (rank-sum test, N.S.: not significant). h Distribution of the baseline AD-pattern scores in future dementia-first converters (blue) and parkinsonism-first converters (red) in the iRBD cohort (rank-sum test, N.S.: not significant). i Group comparison of mean cortical thickness across different groups. The error bar represents the mean and standard error mean (sem), respectively. The P values were calculated with Kruskal–Wallis test with Dunn’s post-hoc test. (**P < 0.01, *** P < 0.001). j Distribution of baseline mean cortical thickness scores of future converters (orange) and non-converters (gray) in total iRBD patients. Rank-sum test, *P < 0.05. k Distribution of baseline mean cortical thickness scores in future dementia-first converters (blue) and parkinsonism-first converters (red) in the iRBD cohort. Rank-sum test, N.S.: not significant

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