Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases

Table 4 Relative suicide and dementia risk of cases with argyrophilic grain disease (AGD) and comorbid pathologies

Pathological comorbidity	Relative suicide risk	Relative dementia risk	Control group
AGD	1.72 (1.30–2.26)^####	1.38 (1.00–1.93)	AGD(−)
AGD + AD (high)	0.88 (0.38–2.10)	3.75 (1.93–7.29)^####	AGD(−) and AD (none, low, or intermediate)
AGD + Lewy	2.27 (1.20–4.30)^##	1.73 (0.99–3.02)^#	AGD(−) and Lewy(−)
AGD + TDP-43	2.20 (0.83–5.81)	1.0 (0.58–1.74)	AGD(−) and TDP-43(−)
AGD + PSP	6.50 (1.58–26.76)^##	1.5 (0.60–3.78)	AGD(−) and PSP(−)

AGD argyrophilic grain disease; AD Alzheimer’s disease; Lewy Lewy body pathology, TDP-43 TAR DNA binding protein 43; PSP progressive supranuclear palsy, ^#P < 0.05; ^##P < 0.01; ^####P < 0.0001 chi-square vs. negative cases

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