Table 2 Clinicopathological features of argyrophilic grain disease (AGD) and AGD-negative cases
|  | Positive cases (n = 342) | Negative cases (n = 1107) | Age- and sex-matched positive cases (n = 314) | Age- and sex-matched negative cases (n = 314) | Age-, sex-, and comorbid pathology-matched positive cases (n = 313) | Age-, sex- and comorbid pathology-matched negative cases (n = 313) |
|---|---|---|---|---|---|---|
Age, mean ± SD, years | 79.7 ± 9.0**** | 67.0 ± 14.1 | 78.8 ± 8.7 | 78.8 ± 8.7 | 79.0 ± 8.9 | 79.5 ± 9.0 |
Sex (male/female) | 177/165#### | 704/403 | 170/144 | 166/148 | 168/145 | 169/144 |
BMI, mean ± SD | 20.1 ± 3.6**** | 21.3 ± 4.5 | 20.3 ± 3.6 | 20.2 ± 3.9 | 20.2 ± 3.6 | 20.1 ± 3.7 |
Cause of death | ||||||
 Suicide, n (%) | 109 (31.9) | 286 (25.8) | 100 (31.9)## | 64 (20.4) | 103 (32.9)#### | 50 (20.2) |
 Homicide, n (%) | 2 (0.6) | 21 (1.9) | 1 (0.3) | 3 (1.0) | 1 (0.3) | 5 (1.6) |
 Accidental death, n (%) | 175 (51.2)# | 494 (44.6) | 162 (51.6) | 175 (55.7) | 158 (50.5) | 172 (55.0) |
 Natural causes, n (%) | 52 (15.2)#### | 297 (26.8) | 47 (15.0)# | 71 (22.6) | 48 (15.3)# | 73 (23.3) |
Past medical history | ||||||
 Dementia, n (%) | 80 (23.4)#### | 78 (7.1) | 73 (23.3)## | 42 (13.4) | 68 (21.7) | 49 (15.7) |
 Medical history of psychiatric disease, n (%) | 51 (14.9) | 161 (14.5) | 50 (15.9) | 37 (11.8) | 49 (15.7)# | 29 (9.3) |
Pathological findings | ||||||
 Brain weight, mean ± SD, g | 1299.8 ± 145.6**** | 1360.4 ± 157.9 | 1305.6 ± 145.9 | 1300.3 ± 158.1 | 1304.8 ± 147.1 | 1309.8 ± 163.8 |
 Heart weight, mean ± SD, g | 362.1 ± 76.6** | 380.4 ± 96.8 | 363.9 ± 76.3 | 375.2 ± 85.6 | 362.1 ± 74.4 | 370.1 ± 84.3 |
 Braak AD tau stage, mean ± SD | 3.5 ± 1.3**** | 2.1 ± 1.6 | 3.5 ± 1.3**** | 3.1 ± 1.5 | 3.4 ± 1.2 | 3.5 ± 1.3 |
 Thal amyloid beta phase, mean ± SD | 1.8 ± 1.6**** | 1.1 ± 1.4 | 1.7 ± 1.6 | 1.8 ± 1.5 | 1.8 ± 1.6 | 1.9 ± 1.6 |
 CERAD amyloid beta stage, mean ± SD | 1.3 ± 1.2**** | 0.8 ± 1.1 | 1.3 ± 1.2 | 1.4 ± 1.2 | 1.3 ± 1.2 | 1.4 ± 1.3 |
 AD criteria in NIA-AA, High, n (%) | 51 (14.9)#### | 77 (7.0) | 49 (15.6) | 41 (13.1) | 42 (13.4) | 59 (18.9) |
 Lewy pathology, n (%) | 92 (26.9)#### | 144 (13.0) | 84 (26.8)# | 63 (20.1) | 80 (25.6) | 67 (21.4) |
 TDP-43 proteinopathy, n (%) | 46 (13.5)#### | 25 (2.3) | 41 (13.1)## | 19 (6.1) | 27 (8.6) | 19 (6.1) |
 PSP pathology, n (%) | 44 (12.9)#### | 31 (2.8) | 38 (12.1)## | 16 (5.1) | 32 (10.2) | 24 (7.7) |