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Table 1 Prevalence rates of argyrophilic grain disease (AGD) in previous studies and the current study

From: Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases

Study (year)

Number of cases (prevalence rate)

Mean age ± SD of AGD cases (in population)

Male/female ratio of AGD cases (in population)

Case selection method

Martinez-Lage and Munoz (1997) [41]

17/300 (5.6%)

77.0 ± 5.1 (61.3 ± 15.8)

8/9 (167/133)

Silver

Braak and Braak [5]

125/2536 (4.9%)

77.0 ± 8.8 (NA)

59/66 (NA)

Silver

Saito et al. (2004) [11]

449/1241 (36.2%)

NA (80.6 ± 8.9)

NA

Silver + immunohistochemistry

Togo et al. (2005) [19]

33/836 (8.5%)

83.7 ± 7.4 (79.9 ± NA)

15/18 (187/199)

Silver

Josephs et al. (2008) [39] 

57/359 (15.9%)

NA

NA

Silver + immunohistochemistry

Rodriguez et al. (2016) [7]

152/983 (15.5%)

78.9 ± 9.4 (74.0 ± 11.7)

59/93 (473/510)

Immunohistochemistry

Current study (2023)

342/1449 (23.6%)

79.7 ± 9.0 (70.0 ± 14.1)

177/165 (881/568)

Silver

 Study (year)

Under 60 years

60–69 years

70–79 years

Over 79 years

Prevalence in each age group

 Saito et al. (2004) [11]

0% (0/14)

17.6% (19/108)

31.2% (132/423)

42.8% (298/696)

 Ferrer et al. (2008) [15]

10% (NA)

*Under 61 years

17% (NA)

*61–70 years

30% (NA)

*71–80 years

43% (NA)

*Over 80 years

 Current study 2023)

2.9% (10/346)

11.9% (35/294)

26.1% (97/371)

45.7% (200/438)

  1. AGD argyrophilic grain disease, NA not applicable, SD standard deviation