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Fig. 4 | Translational Neurodegeneration

Fig. 4

From: Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

Fig. 4

al Immunostaining against tyrosine hydroxylase (TH, red) and choline acetyltransferase (ChAT, green) in a section of the human retina showing examples of connections between ChAT-positive cells and TH-positive cells at the level of S1/S2 (af, arrowheads) and at the level of S3/S4 (gl, arrowheads) in the IPL. mo Retinal sections immunostained against TH (red), ChAT (green) and vesicular monoamine transporter 2 (VMAT2, blue). pa’ Examples of connections between ChAT-positive cell somata (pu, arrowheads) and dendrites (va’, arrowheads) with dopaminergic cell dendrites (TH, red) containing VMAT2 (blue). S1/S2: stratum 1 and 2 in the IPL. S3/S4: stratum 3 and 4 in the IPL. Scale bars: 2.5 μm (al). 20 μm (mo). 5 μm (pa’)

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