Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases

Table 1 Performance of seed amplification assays of olfactory mucosa samples in different neurodegenerative diseases

Disease	Number of cases	Number of controls	Sensitivity (%)	Specificity (%)	References
CJD	31	43	97	100	[17]
CJD	69	17	94	100	[26]
FFI	2	26	100	100	[43]
PD	18	18	56	17	[44]
MSA	11	18	82	17	[44]
CJD	9	19	100	100	[45]
CJD	35	7	91	100	[46]
PD	13	11	69	100	[47]
MSA-P	20	11	90	100	[47]
MSA-C	10	11	0	100	[47]
RBD	63	59	44.4	89.8	[48]
PD	41	59	46.3	89.8	[48]
PD	43	29	74	90	[49]
CJD	29	34	79.3	100	[50]
PSP	4	0	50	–	[93]
CBD	2	0	50	–	[93]
AD	2	0	0	–	[93]

CJD Creutzfeldt–Jakob disease, FFI Fatal Familial Insomnia, PD Parkinson's disease, MSA multiple system atrophy, MSA-P MSA patients with the parkinsonian phenotype, MSA-C MSA patients with the cerebellar phenotype, RBD Isolated REM sleep behaviour disorder, PSP Progressive supranuclear palsy, CBD Corticobasal degeneration, AD Alzheimer’s disease

ISSN: 2047-9158