Skip to main content
Fig. 1 | Translational Neurodegeneration

Fig. 1

From: Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Fig. 1

Exercise improves cognitive function by promoting the production of BDNF. During exercise, the amount of BDNF mRNA exons increases, resulting in increased production of BDNF. BDNF enters the brain through the BBB and binds to the TrkB receptor on the cell membrane to activate intracellular signal transduction. ① The BDNF-TrkB complex activates the PI3K/Akt signaling pathway and regulates the survival of neurons. ② The BDNF-TrkB complex activates the MAPK/Ras/ERK signaling pathway and promotes neuronal differentiation. ③ The BDNF-TrkB complex activates the PLC-γ/PKC signaling pathway and regulates synaptic plasticity

Back to article page

Translational Neurodegeneration

ISSN: 2047-9158

Contact us